Tissue expression of SERPINB2 - Summary - The Human Protein Atlas

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SERPINB2

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TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	SERPINB2
Gene description	Serpin peptidase inhibitor, clade B (ovalbumin), member 2
Protein class	Cancer-related genes FDA approved drug targets Plasma proteins Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Group enriched (esophagus, skin, tonsil, placenta)
GTEx:	Tissue enhanced (esophagus)
FANTOM5:	Group enriched (placenta, esophagus, tonsil)

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in placenta and squamous epithelia.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.
Reliability score	Supported based on 1 antibody. HPA015480
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Group enriched (esophagus, skin, tonsil, placenta)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (esophagus)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Group enriched (placenta, esophagus, tonsil)

GENE INFORMATION
Gene name	SERPINB2 (HGNC Symbol)
Synonyms	HsT1201, PAI2, PLANH2
Description	Serpin peptidase inhibitor, clade B (ovalbumin), member 2 (HGNC Symbol)
Entrez gene summary
Chromosome	18
Cytoband
Chromosome location (bp)	63871692 - 63903890
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000197632 (version 83.38)
Entrez gene	5055
UniProt	P05120 (UniProt - Evidence at protein level)
neXtProt	NX_P05120
Antibodypedia	SERPINB2 antibodies

PROTEIN BROWSER

SERPINB2-001	SERPINB2-002	SERPINB2-003	SERPINB2-005	SERPINB2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SERPINB2-001 ENSP00000299502 ENST00000299502	P05120 [Direct mapping] Plasminogen activator inhibitor 2 Show all	MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Biotech drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0007596 [blood coagulation] GO:0010951 [negative regulation of endopeptidase activity] GO:0042730 [fibrinolysis] GO:0043066 [negative regulation of apoptotic process] Show all	415 aa 46.6 kDa	Yes	0
SERPINB2-002 ENSP00000402386 ENST00000413956	E7EPJ9 [Direct mapping] Plasminogen activator inhibitor 2 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005615 [extracellular space] GO:0010951 [negative regulation of endopeptidase activity] GO:0043066 [negative regulation of apoptotic process] Show all	161 aa 17.8 kDa	Yes	0
SERPINB2-003 ENSP00000397096 ENST00000443281	E7ERB5 [Direct mapping] Plasminogen activator inhibitor 2 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005615 [extracellular space] GO:0010951 [negative regulation of endopeptidase activity] GO:0043066 [negative regulation of apoptotic process] Show all	132 aa 14.4 kDa	Yes	0
SERPINB2-005 ENSP00000385397 ENST00000404622	E9PDK7 [Direct mapping] Plasminogen activator inhibitor 2 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005615 [extracellular space] GO:0010951 [negative regulation of endopeptidase activity] GO:0043066 [negative regulation of apoptotic process] Show all	113 aa 12.3 kDa	Yes	0
SERPINB2-201 ENSP00000401645 ENST00000457692	P05120 [Direct mapping] Plasminogen activator inhibitor 2 Show all	MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Biotech drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0007596 [blood coagulation] GO:0010951 [negative regulation of endopeptidase activity] GO:0042060 [wound healing] GO:0042730 [fibrinolysis] GO:0043066 [negative regulation of apoptotic process] Show all	415 aa 46.6 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.