Expression of PDCD1LG2 in cancer - Summary

CANCER ATLAS

Gene description

Programmed cell death 1 ligand 2

Protein class

Cancer-related genes, CD markers, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA013411

GENE INFORMATION
Gene name	PDCD1LG2 (HGNC Symbol)
Synonyms	B7-DC, bA574F11.2, Btdc, CD273, PD-L2, PDL2
Description	Programmed cell death 1 ligand 2 (HGNC Symbol)
Entrez gene summary
Chromosome	9
Cytoband	p24.1
Chromosome location (bp)	5510570 - 5571254
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000197646 (version 83.38)
Entrez gene	80380
UniProt	Q9BQ51 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BQ51
Antibodypedia	PDCD1LG2 antibodies

PROTEIN BROWSER

PDCD1LG2-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PDCD1LG2-001 ENSP00000380855 ENST00000397747	Q9BQ51 [Direct mapping] Programmed cell death 1 ligand 2 Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006955 [immune response] GO:0012505 [endomembrane system] GO:0016021 [integral component of membrane] GO:0031295 [T cell costimulation] GO:0032689 [negative regulation of interferon-gamma production] GO:0032693 [negative regulation of interleukin-10 production] GO:0042102 [positive regulation of T cell proliferation] GO:0042130 [negative regulation of T cell proliferation] GO:0046007 [negative regulation of activated T cell proliferation] GO:0070062 [extracellular exosome] Show all	273 aa 31 kDa	Yes	1