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PARVA

GENERAL INFORMATION

Gene name

 PARVA

Gene description

 Parvin, alpha

Protein class

 Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous cytoplasmic expression, including in smooth muscle.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA005964
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Smooth muscle

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 PARVA (HGNC Symbol)

Synonyms

 FLJ10793, FLJ12254, MXRA2

Description

 Parvin, alpha (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the parvin family of actin-binding proteins. Parvins are associated with focal contacts and contain calponin homology domains that bind to actin filaments. The encoded protein is part of the integrin-linked kinase signaling complex and plays a role in cell adhesion, motility and survival. [provided by RefSeq, Dec 2010]

Chromosome

 11

Cytoband

 p15.3

Chromosome location (bp)

 12377185 - 12530801

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000197702 (version 83.38)

Entrez gene

 55742

UniProt

neXtProt

Antibodypedia

 PARVA antibodies

PROTEIN BROWSER
PARVA-001
PARVA-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PARVA-001
ENSP00000334008
ENST00000334956
J3KNQ4 [Direct mapping]
Alpha-parvin; Parvin, alpha, isoform CRA_c
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0002040 [sprouting angiogenesis]
GO:0003148 [outflow tract septum morphogenesis]
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005925 [focal adhesion]
GO:0007155 [cell adhesion]
GO:0007163 [establishment or maintenance of cell polarity]
GO:0015629 [actin cytoskeleton]
GO:0030027 [lamellipodium]
GO:0031532 [actin cytoskeleton reorganization]
GO:0034113 [heterotypic cell-cell adhesion]
GO:0070252 [actin-mediated cell contraction]
GO:0071670 [smooth muscle cell chemotaxis]
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 412 aa
46.6 kDa 		No 1
PARVA-004
ENSP00000435860
ENST00000528916
E9PS97 [Direct mapping]
Alpha-parvin
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   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005925 [focal adhesion]
GO:0007155 [cell adhesion]
GO:0015629 [actin cytoskeleton]
GO:0031532 [actin cytoskeleton reorganization]
Show all
 209 aa
23.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.