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KLHL14

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GENERAL INFORMATION

Gene name

 KLHL14

Gene description

 Kelch-like family member 14

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the cytosol. In addition localized to the actin filaments.

RNA cell category

 Cell line enhanced (Hep G2, RPTEC TERT1, REH, SCLC-21H)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Cytosol (supported)

Additional location

 In addition localized to the Actin filaments (approved)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA024777
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (Hep G2, RPTEC TERT1, REH, SCLC-21H)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the cytosol. In addition localized to the actin filaments.

Main location

 Cytosol (supported)

Additional location

 Actin filaments (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA024777 Hep G2 Aggresome
Cytosol
HPA024777 U-2 OS Actin filaments
Cytosol

GENE INFORMATION

Gene name

 KLHL14 (HGNC Symbol)

Synonyms

 KIAA1384

Description

 Kelch-like family member 14 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the Kelch-like gene family, whose members contain a BTB/POZ domain, a BACK domain, and several Kelch domains. The encoded protein possesses six Kelch domains and localizes to the endoplasmic reticulum, where it interacts with torsin-1A. [provided by RefSeq, Sep 2015]

Chromosome

 18

Cytoband

 q12.1

Chromosome location (bp)

 32672671 - 32773062

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000197705 (version 83.38)

Entrez gene

 57565

UniProt

 Q9P2G3 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9P2G3

Antibodypedia

 KLHL14 antibodies

PROTEIN BROWSER
KLHL14-001
KLHL14-002
KLHL14-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KLHL14-001
ENSP00000352314
ENST00000359358
Q9P2G3 [Direct mapping]
Kelch-like protein 14
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   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0016567 [protein ubiquitination]
GO:0031463 [Cul3-RING ubiquitin ligase complex]
GO:0043005 [neuron projection]
GO:0043025 [neuronal cell body]
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 628 aa
70.7 kDa 		No 0
KLHL14-002
ENSP00000350808
ENST00000358095
Q9P2G3 [Direct mapping]
Kelch-like protein 14
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   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0016567 [protein ubiquitination]
GO:0031463 [Cul3-RING ubiquitin ligase complex]
GO:0043005 [neuron projection]
GO:0043025 [neuronal cell body]
Show all
 388 aa
43.8 kDa 		No 0
KLHL14-003
ENSP00000463803
ENST00000583263
J3QQM3 [Direct mapping]
Kelch-like protein 14
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   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
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 227 aa
24.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.