We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Most malignant tissues exhibited weak to moderate cytoplasmic and/or nuclear positivity. Few cases of papillary adenocarcinomas of thyroid, a single case each of seminoma and low grade adenocarcinoma of prostate were strongly stained. Several malignant gliomas, skin, renal and endometrial cancers were negative.
GENE INFORMATION
Gene name
ZNF460 (HGNC Symbol)
Synonyms
HZF8, ZNF272
Description
Zinc finger protein 460 (HGNC Symbol)
Entrez gene summary
Zinc finger proteins, such as ZNF272, interact with nucleic acids and have diverse functions. The zinc finger domain is a conserved amino acid sequence motif containing 2 specifically positioned cysteines and 2 histidines that are involved in coordinating zinc. Kruppel-related proteins form 1 family of zinc finger proteins. See ZFP93 (MIM 604749) for additional information on zinc finger proteins.[supplied by OMIM, May 2004]
Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0003676 [nucleic acid binding] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0046872 [metal ion binding]
