Expression of EME2 in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Essential meiotic structure-specific endonuclease subunit 2

Protein class

Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA045770

GENE INFORMATION
Gene name	EME2 (HGNC Symbol)
Synonyms	FLJ00151, SLX2B
Description	Essential meiotic structure-specific endonuclease subunit 2 (HGNC Symbol)
Entrez gene summary	EME2 forms a heterodimer with MUS81 (MIM 606591) that functions as an XPF (MIM 278760)-type flap/fork endonuclease in DNA repair (Ciccia et al., 2007 [PubMed 17289582]).[supplied by OMIM, Mar 2008]
Chromosome	16
Cytoband	p13.3
Chromosome location (bp)	1773207 - 1781708
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000197774 (version 83.38)
Entrez gene	197342
UniProt	A4GXA9 (UniProt - Evidence at protein level)
neXtProt	NX_A4GXA9
Antibodypedia	EME2 antibodies

PROTEIN BROWSER

EME2-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
EME2-001 ENSP00000457353 ENST00000568449	A4GXA9 [Direct mapping] Probable crossover junction endonuclease EME2 Show all	Predicted intracellular proteins Show all	GO:0003677 [DNA binding] GO:0004518 [nuclease activity] GO:0004519 [endonuclease activity] GO:0005634 [nucleus] GO:0006281 [DNA repair] GO:0006310 [DNA recombination] GO:0090305 [nucleic acid phosphodiester bond hydrolysis] Show all	379 aa 41.2 kDa	No	0