Cell atlas - GPAA1 - The Human Protein Atlas

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GPAA1

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	GPAA1
Gene description	Glycosylphosphatidylinositol anchor attachment 1
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	5
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	GPAA1 (HGNC Symbol)
Synonyms	GAA1, hGAA1
Description	Glycosylphosphatidylinositol anchor attachment 1 (HGNC Symbol)
Entrez gene summary	Posttranslational glycosylphosphatidylinositol (GPI) anchor attachment serves as a general mechanism for linking proteins to the cell surface membrane. The protein encoded by this gene presumably functions in GPI anchoring at the GPI transfer step. The mRNA transcript is ubiquitously expressed in both fetal and adult tissues. The anchor attachment protein 1 contains an N-terminal signal sequence, 1 cAMP- and cGMP-dependent protein kinase phosphorylation site, 1 leucine zipper pattern, 2 potential N-glycosylation sites, and 8 putative transmembrane domains. [provided by RefSeq, Jul 2008]
Chromosome	8
Cytoband	q24.3
Chromosome location (bp)	144082590 - 144086216
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000197858 (version 83.38)
Entrez gene	8733
UniProt	O43292 (UniProt - Evidence at protein level)
neXtProt	NX_O43292
Antibodypedia	GPAA1 antibodies

PROTEIN BROWSER

GPAA1-001	GPAA1-002	GPAA1-008	GPAA1-014	GPAA1-016

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GPAA1-001 ENSP00000347206 ENST00000355091	O43292 [Direct mapping] Glycosylphosphatidylinositol anchor attachment 1 protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003923 [GPI-anchor transamidase activity] GO:0005515 [protein binding] GO:0005789 [endoplasmic reticulum membrane] GO:0006461 [protein complex assembly] GO:0006501 [C-terminal protein lipidation] GO:0006621 [protein retention in ER lumen] GO:0015631 [tubulin binding] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016255 [attachment of GPI anchor to protein] GO:0034235 [GPI anchor binding] GO:0042765 [GPI-anchor transamidase complex] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] Show all	621 aa 67.6 kDa	No	8
GPAA1-002 ENSP00000354316 ENST00000361036	O43292 [Direct mapping] Glycosylphosphatidylinositol anchor attachment 1 protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003923 [GPI-anchor transamidase activity] GO:0005515 [protein binding] GO:0005789 [endoplasmic reticulum membrane] GO:0006461 [protein complex assembly] GO:0006501 [C-terminal protein lipidation] GO:0006621 [protein retention in ER lumen] GO:0015631 [tubulin binding] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016255 [attachment of GPI anchor to protein] GO:0034235 [GPI anchor binding] GO:0042765 [GPI-anchor transamidase complex] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] Show all	561 aa 61.1 kDa	No	6
GPAA1-008 ENSP00000435132 ENST00000530258	E9PLG8 [Direct mapping] Glycosylphosphatidylinositol anchor attachment 1 protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0042765 [GPI-anchor transamidase complex] Show all	81 aa 9.2 kDa	No	0
GPAA1-014 ENSP00000434485 ENST00000525087	E9PQ31 [Direct mapping] Glycosylphosphatidylinositol anchor attachment 1 protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] GO:0042765 [GPI-anchor transamidase complex] Show all	273 aa 30 kDa	No	1
GPAA1-016 ENSP00000434544 ENST00000524418	E9PPZ9 [Direct mapping] Glycosylphosphatidylinositol anchor attachment 1 protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] GO:0042765 [GPI-anchor transamidase complex] Show all	260 aa 28.2 kDa	No	1

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.