Cell atlas - SLC22A12 - The Human Protein Atlas

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SLC22A12

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TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	SLC22A12
Gene description	Solute carrier family 22 (organic anion/urate transporter), member 12
Protein class	Disease related genes Potential drug targets Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	5
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Not detected
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Not detected Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	SLC22A12 (HGNC Symbol)
Synonyms	OAT4L, RST, URAT1
Description	Solute carrier family 22 (organic anion/urate transporter), member 12 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the organic anion transporter (OAT) family, and it acts as a urate transporter to regulate urate levels in blood. This protein is an integral membrane protein primarily found in epithelial cells of the proximal tubule of the kidney. An elevated level of serum urate, hyperuricemia, is associated with increased incidences of gout, and mutations in this gene cause renal hypouricemia type 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
Chromosome	11
Cytoband	q13.1
Chromosome location (bp)	64590641 - 64602353
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000197891 (version 83.38)
Entrez gene	116085
UniProt	Q96S37 (UniProt - Evidence at protein level)
neXtProt	NX_Q96S37
Antibodypedia	SLC22A12 antibodies

PROTEIN BROWSER

SLC22A12-001	SLC22A12-002	SLC22A12-004	SLC22A12-005	SLC22A12-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC22A12-001 ENSP00000366797 ENST00000377574	Q96S37 [Direct mapping] Solute carrier family 22 member 12 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Show all	GO:0005452 [inorganic anion exchanger activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0015143 [urate transmembrane transporter activity] GO:0015347 [sodium-independent organic anion transmembrane transporter activity] GO:0015747 [urate transport] GO:0016021 [integral component of membrane] GO:0016324 [apical plasma membrane] GO:0019725 [cellular homeostasis] GO:0030165 [PDZ domain binding] GO:0031526 [brush border membrane] GO:0042493 [response to drug] GO:0043252 [sodium-independent organic anion transport] GO:0046415 [urate metabolic process] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] GO:0098656 [anion transmembrane transport] GO:1903825 [organic acid transmembrane transport] Show all	553 aa 59.6 kDa	No	>9
SLC22A12-002 ENSP00000366790 ENST00000377567	Q96S37 [Direct mapping] Solute carrier family 22 member 12 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Disease related genes Potential drug targets Show all	GO:0005452 [inorganic anion exchanger activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0015143 [urate transmembrane transporter activity] GO:0015347 [sodium-independent organic anion transmembrane transporter activity] GO:0015747 [urate transport] GO:0016021 [integral component of membrane] GO:0016324 [apical plasma membrane] GO:0019725 [cellular homeostasis] GO:0022857 [transmembrane transporter activity] GO:0030165 [PDZ domain binding] GO:0031526 [brush border membrane] GO:0042493 [response to drug] GO:0043252 [sodium-independent organic anion transport] GO:0046415 [urate metabolic process] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] GO:0098656 [anion transmembrane transport] GO:1903825 [organic acid transmembrane transport] Show all	445 aa 47.6 kDa	No	8
SLC22A12-004 ENSP00000438437 ENST00000473690	Q96S37 [Direct mapping] Solute carrier family 22 member 12 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Show all	GO:0005452 [inorganic anion exchanger activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0015143 [urate transmembrane transporter activity] GO:0015347 [sodium-independent organic anion transmembrane transporter activity] GO:0015747 [urate transport] GO:0016021 [integral component of membrane] GO:0016324 [apical plasma membrane] GO:0019725 [cellular homeostasis] GO:0022857 [transmembrane transporter activity] GO:0030165 [PDZ domain binding] GO:0031526 [brush border membrane] GO:0042493 [response to drug] GO:0043252 [sodium-independent organic anion transport] GO:0046415 [urate metabolic process] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] GO:0098656 [anion transmembrane transport] GO:1903825 [organic acid transmembrane transport] Show all	332 aa 35.6 kDa	No	8
SLC22A12-005 ENSP00000336836 ENST00000336464	Q96S37 [Direct mapping] Solute carrier family 22 member 12 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Show all	GO:0005452 [inorganic anion exchanger activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0015143 [urate transmembrane transporter activity] GO:0015347 [sodium-independent organic anion transmembrane transporter activity] GO:0015747 [urate transport] GO:0016021 [integral component of membrane] GO:0016324 [apical plasma membrane] GO:0019725 [cellular homeostasis] GO:0022857 [transmembrane transporter activity] GO:0030165 [PDZ domain binding] GO:0031526 [brush border membrane] GO:0042493 [response to drug] GO:0043252 [sodium-independent organic anion transport] GO:0046415 [urate metabolic process] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] GO:0098656 [anion transmembrane transport] GO:1903825 [organic acid transmembrane transport] Show all	519 aa 56.1 kDa	No	>9
SLC22A12-201 ENSP00000366795 ENST00000377572	Q96S37 [Direct mapping] Solute carrier family 22 member 12 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Disease related genes Potential drug targets Show all	GO:0005452 [inorganic anion exchanger activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0015143 [urate transmembrane transporter activity] GO:0015347 [sodium-independent organic anion transmembrane transporter activity] GO:0015747 [urate transport] GO:0016021 [integral component of membrane] GO:0016324 [apical plasma membrane] GO:0019725 [cellular homeostasis] GO:0022857 [transmembrane transporter activity] GO:0030165 [PDZ domain binding] GO:0031526 [brush border membrane] GO:0042493 [response to drug] GO:0043252 [sodium-independent organic anion transport] GO:0046415 [urate metabolic process] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] GO:0098656 [anion transmembrane transport] GO:1903825 [organic acid transmembrane transport] Show all	445 aa 47.6 kDa	No	8

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.