Cell atlas - SLC22A6 - The Human Protein Atlas

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SLC22A6

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	SLC22A6
Gene description	Solute carrier family 22 (organic anion transporter), member 6
Protein class	FDA approved drug targets Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	4
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Not detected
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Not detected Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	SLC22A6 (HGNC Symbol)
Synonyms	OAT1, PAHT, ROAT1
Description	Solute carrier family 22 (organic anion transporter), member 6 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is involved in the sodium-dependent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and may be localized to the basolateral membrane. Four transcript variants encoding four different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	11
Cytoband	q12.3
Chromosome location (bp)	62936385 - 62984983
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000197901 (version 83.38)
Entrez gene	9356
UniProt	Q4U2R8 (UniProt - Evidence at protein level)
neXtProt	NX_Q4U2R8
Antibodypedia	SLC22A6 antibodies

PROTEIN BROWSER

SLC22A6-001	SLC22A6-002	SLC22A6-003	SLC22A6-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC22A6-001 ENSP00000353597 ENST00000360421	Q4U2R8 [Direct mapping] Solute carrier family 22 member 6 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Show all	GO:0005452 [inorganic anion exchanger activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0008514 [organic anion transmembrane transporter activity] GO:0015075 [ion transmembrane transporter activity] GO:0015347 [sodium-independent organic anion transmembrane transporter activity] GO:0015711 [organic anion transport] GO:0015742 [alpha-ketoglutarate transport] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0022857 [transmembrane transporter activity] GO:0034220 [ion transmembrane transport] GO:0043252 [sodium-independent organic anion transport] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] GO:0097254 [renal tubular secretion] GO:0098656 [anion transmembrane transport] Show all	550 aa 60.3 kDa	No	>9
SLC22A6-002 ENSP00000367102 ENST00000377871	Q4U2R8 [Direct mapping] Solute carrier family 22 member 6 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Show all	GO:0005452 [inorganic anion exchanger activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005901 [caveola] GO:0006820 [anion transport] GO:0008514 [organic anion transmembrane transporter activity] GO:0015075 [ion transmembrane transporter activity] GO:0015301 [anion:anion antiporter activity] GO:0015347 [sodium-independent organic anion transmembrane transporter activity] GO:0015711 [organic anion transport] GO:0015742 [alpha-ketoglutarate transport] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0022857 [transmembrane transporter activity] GO:0031404 [chloride ion binding] GO:0031427 [response to methotrexate] GO:0034220 [ion transmembrane transport] GO:0042803 [protein homodimerization activity] GO:0043234 [protein complex] GO:0043252 [sodium-independent organic anion transport] GO:0051260 [protein homooligomerization] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] GO:0097254 [renal tubular secretion] GO:0098656 [anion transmembrane transport] Show all	563 aa 61.8 kDa	No	>9
SLC22A6-003 ENSP00000396401 ENST00000458333	Q4U2R8 [Direct mapping] Solute carrier family 22 member 6 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Show all	GO:0005452 [inorganic anion exchanger activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0008514 [organic anion transmembrane transporter activity] GO:0015075 [ion transmembrane transporter activity] GO:0015347 [sodium-independent organic anion transmembrane transporter activity] GO:0015711 [organic anion transport] GO:0015742 [alpha-ketoglutarate transport] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0022857 [transmembrane transporter activity] GO:0034220 [ion transmembrane transport] GO:0043252 [sodium-independent organic anion transport] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] GO:0097254 [renal tubular secretion] GO:0098656 [anion transmembrane transport] Show all	506 aa 55.9 kDa	No	>9
SLC22A6-004 ENSP00000404441 ENST00000421062	Q4U2R8 [Direct mapping] Solute carrier family 22 member 6 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Show all	GO:0005452 [inorganic anion exchanger activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0008514 [organic anion transmembrane transporter activity] GO:0015075 [ion transmembrane transporter activity] GO:0015347 [sodium-independent organic anion transmembrane transporter activity] GO:0015711 [organic anion transport] GO:0015742 [alpha-ketoglutarate transport] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0022857 [transmembrane transporter activity] GO:0034220 [ion transmembrane transport] GO:0043252 [sodium-independent organic anion transport] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] GO:0097254 [renal tubular secretion] GO:0098656 [anion transmembrane transport] Show all	519 aa 57.4 kDa	No	>9

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.