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HES5

GENERAL INFORMATION

Gene name

 HES5

Gene description

 Hes family bHLH transcription factor 5

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (cerebral cortex)
GTEx:Tissue enhanced (hypothalamus)
FANTOM5:Tissue enhanced (caudate)

Protein evidence

 Evidence at transcript level

DATA RELIABILITY

Reliability score

 Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebral cortex)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (hypothalamus)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (caudate)

GENE INFORMATION

Gene name

 HES5 (HGNC Symbol)

Synonyms

 bHLHb38

Description

 Hes family bHLH transcription factor 5 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of a family of basic helix-loop-helix transcriptional repressors. The protein product of this gene, which is activated downstream of the Notch pathway, regulates cell differentiation in multiple tissues. Disruptions in the normal expression of this gene have been associated with developmental diseases and cancer. [provided by RefSeq, Dec 2008]

Chromosome

 1

Cytoband

 p36.32

Chromosome location (bp)

 2528745 - 2530245

Protein evidence

 Evidence at transcript level (all genes)

Ensembl

 ENSG00000197921 (version 83.38)

Entrez gene

 388585

UniProt

 Q5TA89 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q5TA89

Antibodypedia

 HES5 antibodies

PROTEIN BROWSER
HES5-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HES5-001
ENSP00000367714
ENST00000378453
Q5TA89 [Direct mapping]
Transcription factor HES-5
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Predicted intracellular proteins
Transcription factors
   Basic domains
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003690 [double-stranded DNA binding]
GO:0005515 [protein binding]
GO:0005575 [cellular_component]
GO:0005654 [nucleoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006461 [protein complex assembly]
GO:0007155 [cell adhesion]
GO:0007219 [Notch signaling pathway]
GO:0007224 [smoothened signaling pathway]
GO:0007420 [brain development]
GO:0008134 [transcription factor binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0014003 [oligodendrocyte development]
GO:0021537 [telencephalon development]
GO:0021781 [glial cell fate commitment]
GO:0021861 [forebrain radial glial cell differentiation]
GO:0021915 [neural tube development]
GO:0022010 [central nervous system myelination]
GO:0030182 [neuron differentiation]
GO:0030513 [positive regulation of BMP signaling pathway]
GO:0031641 [regulation of myelination]
GO:0042491 [auditory receptor cell differentiation]
GO:0042517 [positive regulation of tyrosine phosphorylation of Stat3 protein]
GO:0042668 [auditory receptor cell fate determination]
GO:0043010 [camera-type eye development]
GO:0045595 [regulation of cell differentiation]
GO:0045665 [negative regulation of neuron differentiation]
GO:0045747 [positive regulation of Notch signaling pathway]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046427 [positive regulation of JAK-STAT cascade]
GO:0046983 [protein dimerization activity]
GO:0048469 [cell maturation]
GO:0048661 [positive regulation of smooth muscle cell proliferation]
GO:0048708 [astrocyte differentiation]
GO:0048712 [negative regulation of astrocyte differentiation]
GO:0048715 [negative regulation of oligodendrocyte differentiation]
GO:0050767 [regulation of neurogenesis]
GO:0051216 [cartilage development]
GO:0072049 [comma-shaped body morphogenesis]
GO:0072050 [S-shaped body morphogenesis]
GO:0072086 [specification of loop of Henle identity]
GO:0072282 [metanephric nephron tubule morphogenesis]
GO:0097150 [neuronal stem cell population maintenance]
GO:2000737 [negative regulation of stem cell differentiation]
GO:2000974 [negative regulation of pro-B cell differentiation]
GO:2000978 [negative regulation of forebrain neuron differentiation]
GO:2000981 [negative regulation of inner ear receptor cell differentiation]
Show all
 166 aa
18.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.