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The protein encoded by this gene enhances transcriptional activation by ligand-bound nuclear hormone receptors. However, it does this not by direct interaction with the receptor, but by direct interaction with the nuclear hormone receptor transcriptional coactivator NRC. The encoded protein may function by altering local chromatin structure. [provided by RefSeq, Jul 2008]
Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Disease related genes Protein evidence (Ezkurdia et al 2014)
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GO:0000979 [RNA polymerase II core promoter sequence-specific DNA binding] GO:0001701 [in utero embryonic development] GO:0002052 [positive regulation of neuroblast proliferation] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0007420 [brain development] GO:0010468 [regulation of gene expression] GO:0021895 [cerebral cortex neuron differentiation] GO:0035097 [histone methyltransferase complex] GO:0040029 [regulation of gene expression, epigenetic] GO:0044212 [transcription regulatory region DNA binding] GO:0046872 [metal ion binding] GO:0048812 [neuron projection morphogenesis] GO:0048854 [brain morphogenesis] GO:0050671 [positive regulation of lymphocyte proliferation] GO:0050767 [regulation of neurogenesis] GO:0050769 [positive regulation of neurogenesis] GO:0051569 [regulation of histone H3-K4 methylation] GO:0080182 [histone H3-K4 trimethylation]