Tissue expression of AVPR1B - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	AVPR1B
Gene description	Arginine vasopressin receptor 1B
Protein class	FDA approved drug targets G-protein coupled receptors Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Not detected
GTEx:	Tissue enriched (pituitary gland)
FANTOM5:	Tissue enriched (pituitary gland)

Protein evidence

Evidence at transcript level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Not detected
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (pituitary gland)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (pituitary gland)

GENE INFORMATION
Gene name	AVPR1B (HGNC Symbol)
Synonyms	AVPR3
Description	Arginine vasopressin receptor 1B (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene acts as receptor for arginine vasopressin. This receptor belongs to the subfamily of G-protein coupled receptors which includes AVPR1A, V2R and OXT receptors. Its activity is mediated by G proteins which stimulate a phosphatidylinositol-calcium second messenger system. The receptor is primarily located in the anterior pituitary, where it stimulates ACTH release. It is expressed at high levels in ACTH-secreting pituitary adenomas as well as in bronchial carcinoids responsible for the ectopic ACTH syndrome. A spliced antisense transcript of this gene has been reported but its function is not known. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	q32.1
Chromosome location (bp)	206109692 - 206117699
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000198049 (version 83.38)
Entrez gene	553
UniProt	P47901 (UniProt - Evidence at transcript level)
neXtProt	NX_P47901
Antibodypedia	AVPR1B antibodies

PROTEIN BROWSER

AVPR1B-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
AVPR1B-001 ENSP00000356094 ENST00000367126	P47901 [Direct mapping] Vasopressin V1b receptor Show all	Transporters G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM FDA approved drug targets Biotech drugs Small molecule drugs Show all	GO:0001992 [regulation of systemic arterial blood pressure by vasopressin] GO:0004930 [G-protein coupled receptor activity] GO:0005000 [vasopressin receptor activity] GO:0005080 [protein kinase C binding] GO:0005768 [endosome] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007202 [activation of phospholipase C activity] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0016021 [integral component of membrane] GO:0032870 [cellular response to hormone stimulus] GO:0042277 [peptide binding] GO:0045907 [positive regulation of vasoconstriction] GO:1901652 [response to peptide] Show all	424 aa 47 kDa	No	7