We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Fields »
 

Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

Category

Score

Score

Score

Antibodies

Column

 
 
ABOUT
HELP
BLOG
  • THE HUMAN PROTEOME
  • THE HUMAN TISSUES
  • THE HUMAN CELL
  • PROTEIN CLASSES
  • PROTEIN EVIDENCE
    • NEWS
    • BLOG
    • EVENTS
    • PRESS ROOM
    • LEARN
    • DICTIONARY
    • METHODS
    • CELL LINES
  • THE PROJECT
  • INTRODUCTION
  • ORGANIZATION
  • PUBLICATIONS
  • PUBLICATION DATA
  • ANTIBODY SUBMISSION
  • ANTIBODY AVAILABILITY
  • LINKS
  • CONTACT
  • TECHNICAL DATA
  • ANTIBODY VALIDATION
  • ASSAYS & ANNOTATION
  • DISCLAIMER
  • DOWNLOADABLE DATA
  • HELP & FAQ
  • LICENCE & CITATION
  • PRIVACY STATEMENT
  • RELEASE HISTORY
CYP2A7
  • premium

    TISSUE

  • CELL

  • CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

CYP2A7

Gene description

Cytochrome P450, family 2, subfamily A, polypeptide 7

Protein class

Enzymes
Predicted secreted proteins

Predicted localization

Secreted

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Tissue enriched (liver)
GTEx:Tissue enriched (liver)
FANTOM5:Tissue enriched (liver)

Protein evidence

Evidence at protein level

Protein expression

Selective cytoplasmic expression in hepatocytes.

DATA RELIABILITY

Data reliability
description

Antibody staining consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

Supported based on 3 antibodies.
HPA046713 , HPA047262 , CAB033510
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Skin

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (liver)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (liver)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (liver)

GENE INFORMATION

Gene name

CYP2A7 (HGNC Symbol)

Synonyms

CYP2A

Description

Cytochrome P450, family 2, subfamily A, polypeptide 7 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum; its substrate has not yet been determined. This gene, which produces two transcript variants, is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. [provided by RefSeq, Jul 2008]

Chromosome

19

Cytoband

q13.2

Chromosome location (bp)

40875439 - 40882752

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000198077 (version 83.38)

Entrez gene

1549

UniProt

P20853 (UniProt - Evidence at transcript level)

neXtProt

NX_P20853

Antibodypedia

CYP2A7 antibodies

PROTEIN BROWSER

CYP2A7-001
CYP2A7-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CYP2A7-001
ENSP00000301146
ENST00000301146
P20853 [Direct mapping]
Cytochrome P450 2A7
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Show all
GO:0005506 [iron ion binding]
GO:0005737 [cytoplasm]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006805 [xenobiotic metabolic process]
GO:0008392 [arachidonic acid epoxygenase activity]
GO:0008395 [steroid hydroxylase activity]
GO:0009804 [coumarin metabolic process]
GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen]
GO:0016712 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen]
GO:0019373 [epoxygenase P450 pathway]
GO:0019825 [oxygen binding]
GO:0020037 [heme binding]
GO:0042738 [exogenous drug catabolic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0055114 [oxidation-reduction process]
GO:0070330 [aromatase activity]
Show all
494 aa
56.4 kDa
Yes 0
CYP2A7-201
ENSP00000291764
ENST00000291764
F8W816 [Direct mapping]
Cytochrome P450 2A7
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Show all
GO:0005506 [iron ion binding]
GO:0005737 [cytoplasm]
GO:0006805 [xenobiotic metabolic process]
GO:0008392 [arachidonic acid epoxygenase activity]
GO:0008395 [steroid hydroxylase activity]
GO:0009804 [coumarin metabolic process]
GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen]
GO:0016712 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen]
GO:0019373 [epoxygenase P450 pathway]
GO:0020037 [heme binding]
GO:0042738 [exogenous drug catabolic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0055114 [oxidation-reduction process]
Show all
443 aa
50.7 kDa
Yes 0

Contact

  • BLOG
  • PRESS ROOM
  • contact@proteinatlas.org

The Project

  • INTRODUCTION
  • ORGANIZATION
  • PUBLICATIONS
  • DOWNLOADABLE DATA

The Human Protein Atlas

  • ANTIBODY AVAILABILITY
  • LICENCE & CITATION
  • HELP & FAQ
The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.