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A few cases of malignant lymphomas, testicular and urothelial cancers exhibited weak to moderate nuclear positivity. A fraction of malignant cells in rare cases of prostate cancers showed strong cytoplasmic staining. Remaining malignant cells were negative.
GENE INFORMATION
Gene name
DEFB107B (HGNC Symbol)
Synonyms
HsT21816
Description
Defensin, beta 107B (HGNC Symbol)
Entrez gene summary
Defensins form a family of antimicrobial and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: alpha-defensins, beta-defensins and theta-defensins. All beta-defensin genes are densely clustered in four to five syntenic chromosomal regions. Chromosome 8p23 contains at least two copies of the duplicated beta-defensin cluster. This duplication results in two identical copies of defensin, beta 107, DEFB107A and DEFB107B, in tail-to-tail orientation. This gene, DEFB107B, represents the more telomeric copy. [provided by RefSeq, Oct 2014]
