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MIER1

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GENERAL INFORMATION

Gene name

 MIER1

Gene description

 Mesoderm induction early response 1, transcriptional regulator

Protein class

 Predicted intracellular proteins
Predicted secreted proteins
Transcription factors

Predicted localization

 Intracellular,Secreted

Number of transcripts

 9
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the nucleoplasm.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (validated)

siRNA

 The location(s) are Validated based on siRNA mediated gene silencing.

Mouse

 Localized to the Nucleoplasm in mouse cells.

DATA RELIABILITY

Reliability score

 Validated based on 2 antibodies.
HPA019589 , HPA050306
SHOW MORE

ASSAYS
RNA expression
Human cells
siRNA
Mouse cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the nucleoplasm.

Main location

 Nucleoplasm (validated)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA019589 A-431 Nucleoplasm
HPA019589 U-2 OS Nucleoplasm
HPA019589 U-251 MG Nucleoplasm
HPA050306 A-431 Nucleoplasm
HPA050306 U-2 OS Nucleoplasm
HPA050306 U-251 MG Nucleoplasm

siRNA VALIDATION
 

Relative fluorescence intensity (RFI)

Antibody

 HPA019589

siRNA validation

 Validated: Significant downregulation > 25% by one siRNA.

Analysis performed in

 Nuclear region of segmented cells in 10x-images

siRNA 1

RFI

 30%

p-value

 < 0.01
 

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail 10x

Thumbnail 40x

Antibody

Sample

Cell line
HPA019589 siRNA 1 U-2 OS
HPA019589 scrambled U-2 OS

MOUSE CELLS

Main location

 Nucleoplasm

Mouse gene

 ENSMUSG00000028522 (version 83)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location
HPA050306 NIH 3T3 Nucleoplasm

GENE INFORMATION

Gene name

 MIER1 (HGNC Symbol)

Synonyms

 hMI-ER1, KIAA1610, MI-ER1

Description

 Mesoderm induction early response 1, transcriptional regulator (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein that was first identified in Xenopus laevis by its role in a mesoderm induction early response (MIER). The encoded protein functions as a transcriptional regulator. Alternatively spliced transcript variants encode multiple isoforms, some of which lack a C-terminal nuclear localization signal. [provided by RefSeq, May 2013]

Chromosome

 1

Cytoband

 p31.3

Chromosome location (bp)

 66924895 - 66988619

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000198160 (version 83.38)

Entrez gene

 57708

UniProt

 Q8N108 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8N108

Antibodypedia

 MIER1 antibodies

PROTEIN BROWSER
MIER1-001
MIER1-002
MIER1-003
MIER1-006
MIER1-007
MIER1-008
MIER1-009
MIER1-201
MIER1-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MIER1-001
ENSP00000350321
ENST00000357692
Q8N108 [Direct mapping]
Mesoderm induction early response protein 1
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Transcription factors
   Helix-turn-helix domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0007165 [signal transduction]
GO:0017053 [transcriptional repressor complex]
GO:0031937 [positive regulation of chromatin silencing]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
Show all
 529 aa
60.2 kDa 		Yes 0
MIER1-002
ENSP00000347514
ENST00000355356
Q8N108 [Direct mapping]
Mesoderm induction early response protein 1
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0007165 [signal transduction]
GO:0017053 [transcriptional repressor complex]
GO:0031937 [positive regulation of chromatin silencing]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
Show all
 512 aa
58 kDa 		No 0
MIER1-003
ENSP00000360051
ENST00000371012
Q8N108 [Direct mapping]
Mesoderm induction early response protein 1
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Transcription factors
   Helix-turn-helix domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0007165 [signal transduction]
GO:0017053 [transcriptional repressor complex]
GO:0031937 [positive regulation of chromatin silencing]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
Show all
 81 aa
9.4 kDa 		Yes 0
MIER1-006
ENSP00000360055
ENST00000371016
Q8N108 [Direct mapping]
Mesoderm induction early response protein 1
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Transcription factors
   Helix-turn-helix domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0007165 [signal transduction]
GO:0017053 [transcriptional repressor complex]
GO:0031937 [positive regulation of chromatin silencing]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
Show all
 450 aa
51.4 kDa 		Yes 0
MIER1-007
ENSP00000383821
ENST00000401042
Q8N108 [Direct mapping]
Mesoderm induction early response protein 1
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0007165 [signal transduction]
GO:0017053 [transcriptional repressor complex]
GO:0031937 [positive regulation of chromatin silencing]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
Show all
 433 aa
49.1 kDa 		No 0
MIER1-008
ENSP00000360053
ENST00000371014
Q8N108 [Direct mapping]
Mesoderm induction early response protein 1
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0007165 [signal transduction]
GO:0017053 [transcriptional repressor complex]
GO:0031937 [positive regulation of chromatin silencing]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
Show all
 486 aa
54.5 kDa 		No 0
MIER1-009
ENSP00000383820
ENST00000401041
Q8N108 [Direct mapping]
Mesoderm induction early response protein 1
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0007165 [signal transduction]
GO:0017053 [transcriptional repressor complex]
GO:0031937 [positive regulation of chromatin silencing]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
Show all
 565 aa
63.4 kDa 		No 0
MIER1-201
ENSP00000348253
ENST00000355977
Q8N108 [Direct mapping]
Mesoderm induction early response protein 1
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0007165 [signal transduction]
GO:0017053 [transcriptional repressor complex]
GO:0031937 [positive regulation of chromatin silencing]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
Show all
 370 aa
42.2 kDa 		No 0
MIER1-202
ENSP00000360057
ENST00000371018
Q8N108 [Direct mapping]
Mesoderm induction early response protein 1
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Transcription factors
   Helix-turn-helix domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0007165 [signal transduction]
GO:0017053 [transcriptional repressor complex]
GO:0031937 [positive regulation of chromatin silencing]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
Show all
 470 aa
53.5 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.