Tissue expression of CLEC4C - Summary - The Human Protein Atlas

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CLEC4C

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	CLEC4C
Gene description	C-type lectin domain family 4, member C
Protein class	CD markers Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (lymph node, tonsil, spleen)
GTEx:	Tissue enriched (testis)
FANTOM5:	Tissue enhanced (testis, tonsil)

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in most tissues, most abundant in immune cells.

DATA RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA029432
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (lymph node, tonsil, spleen)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (testis)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (testis, tonsil)

GENE INFORMATION
Gene name	CLEC4C (HGNC Symbol)
Synonyms	BDCA2, CD303, CLECSF11, CLECSF7, DLEC, HECL
Description	C-type lectin domain family 4, member C (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may play a role in dendritic cell function. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Chromosome	12
Cytoband	p13.31
Chromosome location (bp)	7729415 - 7751605
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000198178 (version 83.38)
Entrez gene	170482
UniProt	Q8WTT0 (UniProt - Evidence at protein level)
neXtProt	NX_Q8WTT0
Antibodypedia	CLEC4C antibodies

PROTEIN BROWSER

CLEC4C-001	CLEC4C-003	CLEC4C-004	CLEC4C-005	CLEC4C-006	CLEC4C-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CLEC4C-001 ENSP00000440428 ENST00000542353	Q8WTT0 [Direct mapping] C-type lectin domain family 4 member C Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0002223 [stimulatory C-type lectin receptor signaling pathway] GO:0002250 [adaptive immune response] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] GO:0030246 [carbohydrate binding] GO:0045087 [innate immune response] Show all	213 aa 25 kDa	No	1
CLEC4C-003 ENSP00000353500 ENST00000360345	Q8WTT0 [Direct mapping] C-type lectin domain family 4 member C Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0002223 [stimulatory C-type lectin receptor signaling pathway] GO:0002250 [adaptive immune response] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] GO:0030246 [carbohydrate binding] GO:0045087 [innate immune response] Show all	213 aa 25 kDa	No	1
CLEC4C-004 ENSP00000346648 ENST00000354629	Q8WTT0 [Direct mapping] C-type lectin domain family 4 member C Show all	CD markers Predicted intracellular proteins Show all	GO:0002223 [stimulatory C-type lectin receptor signaling pathway] GO:0002250 [adaptive immune response] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] GO:0030246 [carbohydrate binding] GO:0045087 [innate immune response] Show all	182 aa 21.5 kDa	No	0
CLEC4C-005 ENSP00000442457 ENST00000543765	H0YGB2 [Direct mapping] C-type lectin domain family 4 member C Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Show all	GO:0016021 [integral component of membrane] Show all	138 aa 16.1 kDa	No	0
CLEC4C-006 ENSP00000438649 ENST00000537530	H0YFH6 [Direct mapping] C-type lectin domain family 4 member C Show all	Predicted intracellular proteins Show all		88 aa 10.2 kDa	No	0
CLEC4C-201 ENSP00000445338 ENST00000540085	Q8WTT0 [Direct mapping] C-type lectin domain family 4 member C Show all	CD markers Predicted intracellular proteins Show all	GO:0002223 [stimulatory C-type lectin receptor signaling pathway] GO:0002250 [adaptive immune response] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] GO:0030246 [carbohydrate binding] GO:0045087 [innate immune response] Show all	182 aa 21.5 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.