Expression of SZT2 in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Seizure threshold 2 homolog (mouse)

Protein class

Disease related genes, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA029012

GENE INFORMATION
Gene name	SZT2 (HGNC Symbol)
Synonyms	C1orf84, FLJ10387, FLJ34502, KIAA0467, RP11-506B15.1, SZT2A, SZT2B
Description	Seizure threshold 2 homolog (mouse) (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is expressed in the brain, predominantly in the parietal and frontal cortex as well as in dorsal root ganglia. It is localized to the peroxisome, and is implicated in resistance to oxidative stress. It likely functions by increasing superoxide dismutase (SOD) activity, but itself has no direct SOD activity. Studies in mice show that this gene confers low seizure threshold, and may also enhance epileptogenesis. [provided by RefSeq, Jun 2011]
Chromosome	1
Cytoband	p34.2
Chromosome location (bp)	43389882 - 43452650
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000198198 (version 83.38)
Entrez gene	23334
UniProt	Q5T011 (UniProt - Evidence at protein level)
neXtProt	NX_Q5T011
Antibodypedia	SZT2 antibodies

PROTEIN BROWSER

SZT2-002	SZT2-004	SZT2-015

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SZT2-002 ENSP00000361528 ENST00000372450	Q5T011 [Direct mapping] Protein SZT2 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005777 [peroxisome] GO:0007417 [central nervous system development] GO:0009791 [post-embryonic development] GO:0021540 [corpus callosum morphogenesis] GO:0070062 [extracellular exosome] GO:1901668 [regulation of superoxide dismutase activity] Show all	178 aa 20.3 kDa	No	0
SZT2-004 ENSP00000457168 ENST00000562955	Q5T011 [Direct mapping] Protein SZT2 Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005777 [peroxisome] GO:0007417 [central nervous system development] GO:0009791 [post-embryonic development] GO:0021540 [corpus callosum morphogenesis] GO:0043473 [pigmentation] GO:0070062 [extracellular exosome] GO:1901668 [regulation of superoxide dismutase activity] Show all	3375 aa 371.9 kDa	No	0
SZT2-015 ENSP00000489255 ENST00000634258		Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		3432 aa 378 kDa	No	0