Cell atlas - CACNA1E - The Human Protein Atlas

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CACNA1E

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Actin filaments
	Cytosol
	Plasma membrane

Human cell
	Actin Filaments
	Cytosol
	Plasma Membrane

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GENERAL INFORMATION
Gene name	CACNA1E
Gene description	Calcium channel, voltage-dependent, R type, alpha 1E subunit
Protein class	Predicted membrane proteins Voltage-gated ion channels
Predicted localization	Membrane
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the plasma membrane. In addition localized to the cytosol & actin filaments.
RNA cell category	Cell line enhanced (U-266/70, CACO-2)
Protein evidence	Evidence at protein level
Main location	Localized to the Plasma membrane (approved)
Additional location	In addition localized to the Actin filaments (approved), Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA042515
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (U-266/70, CACO-2) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the plasma membrane. In addition localized to the cytosol & actin filaments.

Main location

Plasma membrane (approved)

Additional location

Actin filaments (approved), Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA042515	A-431	Plasma membrane
	HPA042515	A-431	Cytosol
	HPA042515	CACO-2	Plasma membrane
	HPA042515	U-2 OS	Plasma membrane
			Actin filaments
			Cytosol

GENE INFORMATION
Gene name	CACNA1E (HGNC Symbol)
Synonyms	BII, CACH6, CACNL1A6, Cav2.3
Description	Calcium channel, voltage-dependent, R type, alpha 1E subunit (HGNC Symbol)
Entrez gene summary	Voltage-dependent calcium channels are multisubunit complexes consisting of alpha-1, alpha-2, beta, and delta subunits in a 1:1:1:1 ratio. These channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This gene encodes the alpha-1E subunit of the R-type calcium channels, which belong to the 'high-voltage activated' group that maybe involved in the modulation of firing patterns of neurons important for information processing. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2011]
Chromosome	1
Cytoband	q25.3
Chromosome location (bp)	181413102 - 181808084
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000198216 (version 83.38)
Entrez gene	777
UniProt	Q15878 (UniProt - Evidence at protein level)
neXtProt	NX_Q15878
Antibodypedia	CACNA1E antibodies

PROTEIN BROWSER

CACNA1E-001	CACNA1E-002	CACNA1E-003	CACNA1E-004	CACNA1E-006	CACNA1E-201	CACNA1E-202	CACNA1E-203	CACNA1E-204

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CACNA1E-001 ENSP00000356542 ENST00000367570	Q15878 [Direct mapping] Voltage-dependent R-type calcium channel subunit alpha-1E Show all	Voltage-gated ion channels Voltage-Gated Calcium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005216 [ion channel activity] GO:0005245 [voltage-gated calcium channel activity] GO:0005509 [calcium ion binding] GO:0005886 [plasma membrane] GO:0005891 [voltage-gated calcium channel complex] GO:0006112 [energy reserve metabolic process] GO:0006810 [transport] GO:0006811 [ion transport] GO:0006816 [calcium ion transport] GO:0007268 [synaptic transmission] GO:0008331 [high voltage-gated calcium channel activity] GO:0016020 [membrane] GO:0034220 [ion transmembrane transport] GO:0034765 [regulation of ion transmembrane transport] GO:0044281 [small molecule metabolic process] GO:0050796 [regulation of insulin secretion] GO:0051899 [membrane depolarization] GO:0055085 [transmembrane transport] GO:0070509 [calcium ion import] GO:0086010 [membrane depolarization during action potential] Show all	2270 aa 257.1 kDa	No	>9
CACNA1E-002 ENSP00000481619 ENST00000621791	Q15878 [Direct mapping] Voltage-dependent R-type calcium channel subunit alpha-1E Show all	Voltage-gated ion channels Voltage-Gated Calcium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005216 [ion channel activity] GO:0005245 [voltage-gated calcium channel activity] GO:0005509 [calcium ion binding] GO:0005886 [plasma membrane] GO:0005891 [voltage-gated calcium channel complex] GO:0006112 [energy reserve metabolic process] GO:0006810 [transport] GO:0006811 [ion transport] GO:0006816 [calcium ion transport] GO:0007268 [synaptic transmission] GO:0008331 [high voltage-gated calcium channel activity] GO:0016020 [membrane] GO:0034220 [ion transmembrane transport] GO:0034765 [regulation of ion transmembrane transport] GO:0044281 [small molecule metabolic process] GO:0050796 [regulation of insulin secretion] GO:0051899 [membrane depolarization] GO:0055085 [transmembrane transport] GO:0070509 [calcium ion import] GO:0086010 [membrane depolarization during action potential] Show all	2251 aa 254.6 kDa	No	>9
CACNA1E-003 ENSP00000356545 ENST00000367573	Q15878 [Direct mapping] Voltage-dependent R-type calcium channel subunit alpha-1E Show all	Voltage-gated ion channels Voltage-Gated Calcium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0001662 [behavioral fear response] GO:0002027 [regulation of heart rate] GO:0005216 [ion channel activity] GO:0005245 [voltage-gated calcium channel activity] GO:0005509 [calcium ion binding] GO:0005886 [plasma membrane] GO:0005891 [voltage-gated calcium channel complex] GO:0006112 [energy reserve metabolic process] GO:0006810 [transport] GO:0006811 [ion transport] GO:0006816 [calcium ion transport] GO:0007268 [synaptic transmission] GO:0007626 [locomotory behavior] GO:0008331 [high voltage-gated calcium channel activity] GO:0008542 [visual learning] GO:0016020 [membrane] GO:0019226 [transmission of nerve impulse] GO:0019233 [sensory perception of pain] GO:0030317 [sperm motility] GO:0034220 [ion transmembrane transport] GO:0034765 [regulation of ion transmembrane transport] GO:0042593 [glucose homeostasis] GO:0042596 [fear response] GO:0044281 [small molecule metabolic process] GO:0048265 [response to pain] GO:0048266 [behavioral response to pain] GO:0050796 [regulation of insulin secretion] GO:0050877 [neurological system process] GO:0051899 [membrane depolarization] GO:0055085 [transmembrane transport] GO:0061178 [regulation of insulin secretion involved in cellular response to glucose stimulus] GO:0070509 [calcium ion import] GO:0070588 [calcium ion transmembrane transport] GO:0086010 [membrane depolarization during action potential] GO:0090273 [regulation of somatostatin secretion] Show all	2313 aa 261.7 kDa	No	>9
CACNA1E-004 ENSP00000432038 ENST00000524607	E9PIE8 [Direct mapping] Voltage-dependent R-type calcium channel subunit alpha-1E Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Show all	GO:0005216 [ion channel activity] GO:0005886 [plasma membrane] GO:0005891 [voltage-gated calcium channel complex] GO:0006811 [ion transport] GO:0006816 [calcium ion transport] GO:0008331 [high voltage-gated calcium channel activity] GO:0016020 [membrane] GO:0034220 [ion transmembrane transport] GO:0034765 [regulation of ion transmembrane transport] GO:0055085 [transmembrane transport] GO:0070509 [calcium ion import] GO:0070588 [calcium ion transmembrane transport] GO:0086010 [membrane depolarization during action potential] Show all	438 aa 49.3 kDa	No	6
CACNA1E-006 ENSP00000353222 ENST00000360108	F8W9Z1 [Direct mapping] Voltage-dependent R-type calcium channel subunit alpha-1E Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Show all	GO:0005216 [ion channel activity] GO:0005509 [calcium ion binding] GO:0005886 [plasma membrane] GO:0005891 [voltage-gated calcium channel complex] GO:0006811 [ion transport] GO:0006816 [calcium ion transport] GO:0008331 [high voltage-gated calcium channel activity] GO:0016020 [membrane] GO:0034220 [ion transmembrane transport] GO:0034765 [regulation of ion transmembrane transport] GO:0055085 [transmembrane transport] GO:0070509 [calcium ion import] GO:0070588 [calcium ion transmembrane transport] GO:0086010 [membrane depolarization during action potential] Show all	2294 aa 259.2 kDa	No	>9
CACNA1E-201 ENSP00000350183 ENST00000357570	J3KP11 [Direct mapping] Voltage-dependent R-type calcium channel subunit alpha-1E Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Show all	GO:0005216 [ion channel activity] GO:0005509 [calcium ion binding] GO:0005886 [plasma membrane] GO:0005891 [voltage-gated calcium channel complex] GO:0006811 [ion transport] GO:0006816 [calcium ion transport] GO:0008331 [high voltage-gated calcium channel activity] GO:0016020 [membrane] GO:0034220 [ion transmembrane transport] GO:0034765 [regulation of ion transmembrane transport] GO:0055085 [transmembrane transport] GO:0070509 [calcium ion import] GO:0070588 [calcium ion transmembrane transport] GO:0086010 [membrane depolarization during action potential] Show all	2312 aa 261.9 kDa	No	>9
CACNA1E-202 ENSP00000351101 ENST00000358338	Q15878 [Direct mapping] Voltage-dependent R-type calcium channel subunit alpha-1E Show all	Voltage-gated ion channels Voltage-Gated Calcium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Show all	GO:0005216 [ion channel activity] GO:0005245 [voltage-gated calcium channel activity] GO:0005509 [calcium ion binding] GO:0005886 [plasma membrane] GO:0005891 [voltage-gated calcium channel complex] GO:0006112 [energy reserve metabolic process] GO:0006810 [transport] GO:0006811 [ion transport] GO:0006816 [calcium ion transport] GO:0007268 [synaptic transmission] GO:0008331 [high voltage-gated calcium channel activity] GO:0016020 [membrane] GO:0034220 [ion transmembrane transport] GO:0034765 [regulation of ion transmembrane transport] GO:0044281 [small molecule metabolic process] GO:0050796 [regulation of insulin secretion] GO:0051899 [membrane depolarization] GO:0055085 [transmembrane transport] GO:0070509 [calcium ion import] GO:0086010 [membrane depolarization during action potential] Show all	2251 aa 254.6 kDa	No	>9
CACNA1E-203 ENSP00000356539 ENST00000367567	Q15878 [Direct mapping] Voltage-dependent R-type calcium channel subunit alpha-1E Show all	Voltage-gated ion channels Voltage-Gated Calcium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Show all	GO:0005216 [ion channel activity] GO:0005245 [voltage-gated calcium channel activity] GO:0005509 [calcium ion binding] GO:0005886 [plasma membrane] GO:0005891 [voltage-gated calcium channel complex] GO:0006112 [energy reserve metabolic process] GO:0006810 [transport] GO:0006811 [ion transport] GO:0006816 [calcium ion transport] GO:0007268 [synaptic transmission] GO:0008331 [high voltage-gated calcium channel activity] GO:0016020 [membrane] GO:0034220 [ion transmembrane transport] GO:0034765 [regulation of ion transmembrane transport] GO:0044281 [small molecule metabolic process] GO:0050796 [regulation of insulin secretion] GO:0051899 [membrane depolarization] GO:0055085 [transmembrane transport] GO:0070509 [calcium ion import] GO:0086010 [membrane depolarization during action potential] Show all	2270 aa 257.1 kDa	No	>9
CACNA1E-204 ENSP00000483914 ENST00000621551	Q15878 [Direct mapping] Voltage-dependent R-type calcium channel subunit alpha-1E Show all	Voltage-gated ion channels Voltage-Gated Calcium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Show all	GO:0005216 [ion channel activity] GO:0005245 [voltage-gated calcium channel activity] GO:0005509 [calcium ion binding] GO:0005886 [plasma membrane] GO:0005891 [voltage-gated calcium channel complex] GO:0006112 [energy reserve metabolic process] GO:0006810 [transport] GO:0006811 [ion transport] GO:0006816 [calcium ion transport] GO:0007268 [synaptic transmission] GO:0008331 [high voltage-gated calcium channel activity] GO:0016020 [membrane] GO:0034220 [ion transmembrane transport] GO:0034765 [regulation of ion transmembrane transport] GO:0044281 [small molecule metabolic process] GO:0050796 [regulation of insulin secretion] GO:0051899 [membrane depolarization] GO:0055085 [transmembrane transport] GO:0070509 [calcium ion import] GO:0086010 [membrane depolarization during action potential] Show all	2313 aa 261.7 kDa	No	>9

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.