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CSF2RA

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GENERAL INFORMATION

Gene name

 CSF2RA

Gene description

 Colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)

Protein class

 Cancer-related genes
CD markers
Disease related genes
FDA approved drug targets
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

 Membrane,Secreted

Number of transcripts

 12
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Group enriched (BEWO, SK-MEL-30, HMC-1)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (BEWO, SK-MEL-30, HMC-1)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 CSF2RA (HGNC Symbol)

Synonyms

 CD116, CSF2R

Description

 Colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is the alpha subunit of the heterodimeric receptor for colony stimulating factor 2, a cytokine which controls the production, differentiation, and function of granulocytes and macrophages. The encoded protein is a member of the cytokine family of receptors. This gene is found in the pseudoautosomal region (PAR) of the X and Y chromosomes. Multiple transcript variants encoding different isoforms have been found for this gene, with some of the isoforms being membrane-bound and others being soluble. [provided by RefSeq, Jul 2008]

Chromosome

 X

Cytoband

 p22.33

Chromosome location (bp)

 1268800 - 1310381

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000198223 (version 83.38)

Entrez gene

 1438

UniProt

 P15509 (UniProt - Evidence at protein level)

neXtProt

 NX_P15509

Antibodypedia

 CSF2RA antibodies

PROTEIN BROWSER
«
CSF2RA-001
CSF2RA-002
CSF2RA-004
CSF2RA-005
CSF2RA-006
CSF2RA-007
CSF2RA-009
CSF2RA-010
CSF2RA-012
CSF2RA-201
CSF2RA-202
CSF2RA-203
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CSF2RA-001
ENSP00000370935
ENST00000381524
P15509 [Direct mapping]
Granulocyte-macrophage colony-stimulating factor receptor subunit alpha
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
FDA approved drug targets
   Biotech drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0004872 [receptor activity]
GO:0004896 [cytokine receptor activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0016020 [membrane]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0044267 [cellular protein metabolic process]
GO:0045087 [innate immune response]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
Show all
 400 aa
46.2 kDa 		Yes 1
CSF2RA-002
ENSP00000348058
ENST00000355805
P15509 [Direct mapping]
Granulocyte-macrophage colony-stimulating factor receptor subunit alpha
Show all
CD markers
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
FDA approved drug targets
   Biotech drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0004872 [receptor activity]
GO:0004896 [cytokine receptor activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0016020 [membrane]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0044267 [cellular protein metabolic process]
GO:0045087 [innate immune response]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
Show all
 233 aa
26.6 kDa 		Yes 0
CSF2RA-004
ENSP00000347606
ENST00000355432
P15509 [Direct mapping]
Granulocyte-macrophage colony-stimulating factor receptor subunit alpha
Show all
CD markers
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
FDA approved drug targets
   Biotech drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0004872 [receptor activity]
GO:0004896 [cytokine receptor activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0016020 [membrane]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0044267 [cellular protein metabolic process]
GO:0045087 [innate immune response]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
Show all
 377 aa
43.5 kDa 		Yes 0
CSF2RA-005
ENSP00000370920
ENST00000381509
P15509 [Direct mapping]
Granulocyte-macrophage colony-stimulating factor receptor subunit alpha
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
FDA approved drug targets
   Biotech drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0004872 [receptor activity]
GO:0004896 [cytokine receptor activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0016020 [membrane]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0044267 [cellular protein metabolic process]
GO:0045087 [innate immune response]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
Show all
 410 aa
46.9 kDa 		Yes 1
CSF2RA-006
ENSP00000370940
ENST00000381529
P15509 [Direct mapping]
Granulocyte-macrophage colony-stimulating factor receptor subunit alpha
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
FDA approved drug targets
   Biotech drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0004872 [receptor activity]
GO:0004896 [cytokine receptor activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0016020 [membrane]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0044267 [cellular protein metabolic process]
GO:0045087 [innate immune response]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
Show all
 400 aa
46.2 kDa 		Yes 1
CSF2RA-007
ENSP00000370911
ENST00000381500
P15509 [Direct mapping]
Granulocyte-macrophage colony-stimulating factor receptor subunit alpha
Show all
CD markers
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
FDA approved drug targets
   Biotech drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0004872 [receptor activity]
GO:0004896 [cytokine receptor activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0016020 [membrane]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0044267 [cellular protein metabolic process]
GO:0045087 [innate immune response]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
Show all
 333 aa
38.4 kDa 		Yes 0
CSF2RA-009
ENSP00000410667
ENST00000412290
J3JS74 [Direct mapping]
Granulocyte-macrophage colony-stimulating factor receptor subunit alpha
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004896 [cytokine receptor activity]
GO:0005515 [protein binding]
GO:0016020 [membrane]
GO:0019221 [cytokine-mediated signaling pathway]
Show all
 238 aa
27.4 kDa 		Yes 0
CSF2RA-010
ENSP00000397452
ENST00000419094
J3JS73 [Direct mapping]
Granulocyte-macrophage colony-stimulating factor receptor subunit alpha
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004896 [cytokine receptor activity]
GO:0005515 [protein binding]
GO:0016020 [membrane]
GO:0019221 [cytokine-mediated signaling pathway]
Show all
 188 aa
21.5 kDa 		Yes 0
CSF2RA-012
ENSP00000476684
ENST00000494969
V9GYE9 [Direct mapping]
Granulocyte-macrophage colony-stimulating factor receptor subunit alpha
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 90 aa
10.2 kDa 		Yes 0
CSF2RA-201
ENSP00000394227
ENST00000417535
P15509 [Direct mapping]
Granulocyte-macrophage colony-stimulating factor receptor subunit alpha
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
FDA approved drug targets
   Biotech drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0004872 [receptor activity]
GO:0004896 [cytokine receptor activity]
GO:0004902 [granulocyte colony-stimulating factor receptor activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0016020 [membrane]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038158 [granulocyte colony-stimulating factor signaling pathway]
GO:0044267 [cellular protein metabolic process]
GO:0045087 [innate immune response]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051916 [granulocyte colony-stimulating factor binding]
GO:0097011 [cellular response to granulocyte macrophage colony-stimulating factor stimulus]
Show all
 434 aa
49.9 kDa 		Yes 1
CSF2RA-202
ENSP00000416437
ENST00000432318
P15509 [Direct mapping]
Granulocyte-macrophage colony-stimulating factor receptor subunit alpha
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
FDA approved drug targets
   Biotech drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0004872 [receptor activity]
GO:0004896 [cytokine receptor activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0016020 [membrane]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0044267 [cellular protein metabolic process]
GO:0045087 [innate immune response]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
Show all
 400 aa
46.2 kDa 		Yes 1
CSF2RA-203
ENSP00000440491
ENST00000501036
P15509 [Direct mapping]
Granulocyte-macrophage colony-stimulating factor receptor subunit alpha
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
FDA approved drug targets
   Biotech drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0004872 [receptor activity]
GO:0004896 [cytokine receptor activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0016020 [membrane]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0044267 [cellular protein metabolic process]
GO:0045087 [innate immune response]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
Show all
 267 aa
31.1 kDa 		No 1

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.