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DDX42

CANCER ATLAS

Gene description

 DEAD (Asp-Glu-Ala-Asp) box helicase 42

Protein class

 Enzymes, Plasma proteins, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA023447
HPA023571
HPA025941

GENE INFORMATION

Gene name

 DDX42 (HGNC Symbol)

Synonyms

 RHELP, RNAHP, SF3b125, SF3B8

Description

 DEAD (Asp-Glu-Ala-Asp) box helicase 42 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the Asp-Glu-Ala-Asp (DEAD) box protein family. Members of this protein family are putative RNA helicases, and are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 17

Cytoband

 q23.3

Chromosome location (bp)

 63773603 - 63819317

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000198231 (version 83.38)

Entrez gene

 11325

UniProt

 Q86XP3 (UniProt - Evidence at protein level)

neXtProt

 NX_Q86XP3

Antibodypedia

 DDX42 antibodies

PROTEIN BROWSER
DDX42-001
DDX42-002
DDX42-009
DDX42-010
DDX42-201
DDX42-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DDX42-001
ENSP00000464050
ENST00000578681
Q86XP3 [Direct mapping]
ATP-dependent RNA helicase DDX42
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0004004 [ATP-dependent RNA helicase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0008104 [protein localization]
GO:0010501 [RNA secondary structure unwinding]
GO:0015030 [Cajal body]
GO:0016020 [membrane]
GO:0016607 [nuclear speck]
GO:0044822 [poly(A) RNA binding]
Show all
 938 aa
103 kDa 		No 0
DDX42-002
ENSP00000463561
ENST00000583590
Q86XP3 [Direct mapping]
ATP-dependent RNA helicase DDX42
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0004004 [ATP-dependent RNA helicase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0008104 [protein localization]
GO:0010501 [RNA secondary structure unwinding]
GO:0015030 [Cajal body]
GO:0016020 [membrane]
GO:0016607 [nuclear speck]
GO:0044822 [poly(A) RNA binding]
Show all
 938 aa
103 kDa 		No 0
DDX42-009
ENSP00000464232
ENST00000581135
J3QRI2 [Direct mapping]
ATP-dependent RNA helicase DDX42
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004004 [ATP-dependent RNA helicase activity]
GO:0010501 [RNA secondary structure unwinding]
Show all
 104 aa
11.3 kDa 		No 0
DDX42-010
ENSP00000352308
ENST00000359353
Q86XP3 [Direct mapping]
ATP-dependent RNA helicase DDX42
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0004004 [ATP-dependent RNA helicase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0008104 [protein localization]
GO:0010501 [RNA secondary structure unwinding]
GO:0015030 [Cajal body]
GO:0016020 [membrane]
GO:0016607 [nuclear speck]
GO:0044822 [poly(A) RNA binding]
Show all
 819 aa
90.1 kDa 		No 0
DDX42-201
ENSP00000374574
ENST00000389924
Q86XP3 [Direct mapping]
ATP-dependent RNA helicase DDX42
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0004004 [ATP-dependent RNA helicase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0008104 [protein localization]
GO:0010501 [RNA secondary structure unwinding]
GO:0015030 [Cajal body]
GO:0016020 [membrane]
GO:0016607 [nuclear speck]
GO:0044822 [poly(A) RNA binding]
Show all
 938 aa
103 kDa 		No 0
DDX42-202
ENSP00000390121
ENST00000457800
A0A0A0MSJ0 [Direct mapping]
ATP-dependent RNA helicase DDX42
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0004004 [ATP-dependent RNA helicase activity]
GO:0005524 [ATP binding]
GO:0010501 [RNA secondary structure unwinding]
Show all
 708 aa
77.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.