Cell atlas - SLC29A3 - The Human Protein Atlas

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SLC29A3

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Golgi apparatus
	Vesicles

Human cell
	Golgi Apparatus
	Vesicles

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GENERAL INFORMATION
Gene name	SLC29A3
Gene description	Solute carrier family 29 (equilibrative nucleoside transporter), member 3
Protein class	Disease related genes Potential drug targets Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the Golgi apparatus & vesicles.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Golgi apparatus (approved), Vesicles (supported)

DATA RELIABILITY
Reliability score	Supported based on 2 antibodies. HPA046085 , HPA057905
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the Golgi apparatus & vesicles.

Main location

Golgi apparatus (approved), Vesicles (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA046085	Hep G2	Golgi apparatus
	HPA046085	Hep G2	Vesicles
	HPA057905	Hep G2	Golgi apparatus
	HPA057905	Hep G2	Vesicles

GENE INFORMATION
Gene name	SLC29A3 (HGNC Symbol)
Synonyms	ENT3, FLJ11160
Description	Solute carrier family 29 (equilibrative nucleoside transporter), member 3 (HGNC Symbol)
Entrez gene summary	This gene encodes a nucleoside transporter. The encoded protein plays a role in cellular uptake of nucleosides, nucleobases, and their related analogs. Mutations in this gene have been associated with H syndrome, which is characterized by cutaneous hyperpigmentation and hypertrichosis, hepatosplenomegaly, heart anomalies, and hypogonadism. A related disorder, PHID (pigmented hypertrichosis with insulin-dependent diabetes mellitus), has also been associated with mutations at this locus. Alternatively spliced transcript variants have been described.[provided by RefSeq, Mar 2010]
Chromosome	10
Cytoband	q22.1
Chromosome location (bp)	71319258 - 71363385
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000198246 (version 83.38)
Entrez gene	55315
UniProt	Q9BZD2 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BZD2
Antibodypedia	SLC29A3 antibodies

PROTEIN BROWSER

SLC29A3-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC29A3-001 ENSP00000362285 ENST00000373189	Q9BZD2 [Direct mapping] Equilibrative nucleoside transporter 3 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Show all	GO:0005337 [nucleoside transmembrane transporter activity] GO:0005765 [lysosomal membrane] GO:0006810 [transport] GO:0015858 [nucleoside transport] GO:0016021 [integral component of membrane] GO:0031902 [late endosome membrane] GO:0055085 [transmembrane transport] GO:1901642 [nucleoside transmembrane transport] Show all	475 aa 51.8 kDa	No	>9

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.