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Cancer tissues showed weak to moderate cytoplasmic and/or nuclear positivity. Several cases of carcinoids and prostate cancers were negative.
GENE INFORMATION
Gene name
CARD11 (HGNC Symbol)
Synonyms
BIMP3, CARMA1
Description
Caspase recruitment domain family, member 11 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein has a domain structure similar to that of CARD14 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. When expressed in cells, this protein activated NF-kappaB and induced the phosphorylation of BCL10. [provided by RefSeq, Jul 2008]
Predicted intracellular proteins Cancer-related genes Mutated cancer genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001772 [immunological synapse] GO:0001819 [positive regulation of cytokine production] GO:0002223 [stimulatory C-type lectin receptor signaling pathway] GO:0004385 [guanylate kinase activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0007165 [signal transduction] GO:0030890 [positive regulation of B cell proliferation] GO:0031295 [T cell costimulation] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0042101 [T cell receptor complex] GO:0042102 [positive regulation of T cell proliferation] GO:0042981 [regulation of apoptotic process] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0045061 [thymic T cell selection] GO:0045086 [positive regulation of interleukin-2 biosynthetic process] GO:0045087 [innate immune response] GO:0045121 [membrane raft] GO:0045577 [regulation of B cell differentiation] GO:0045580 [regulation of T cell differentiation] GO:0046037 [GMP metabolic process] GO:0046710 [GDP metabolic process] GO:0050700 [CARD domain binding] GO:0050776 [regulation of immune response] GO:0050852 [T cell receptor signaling pathway] GO:0050870 [positive regulation of T cell activation] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] GO:0070062 [extracellular exosome]
E2QRC0 [Direct mapping] Caspase recruitment domain-containing protein 11
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Predicted intracellular proteins Cancer-related genes Mutated cancer genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Protein evidence (Ezkurdia et al 2014)
H7BY05 [Direct mapping] Caspase recruitment domain-containing protein 11
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Predicted intracellular proteins Cancer-related genes Mutated cancer genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Protein evidence (Ezkurdia et al 2014)
