Cell atlas - PEG3 - The Human Protein Atlas

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PEG3

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	PEG3
Gene description	Paternally expressed 3
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoplasm.
RNA cell category	Cell line enhanced (Hep G2, BEWO, RH-30)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA026070
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (Hep G2, BEWO, RH-30) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoplasm.

Main location

Nucleoplasm (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA026070	Hep G2	Nucleoplasm
	HPA026070	RH-30	Nucleoplasm

GENE INFORMATION
Gene name	PEG3 (HGNC Symbol)
Synonyms	KIAA0287, ZKSCAN22, ZNF904, ZSCAN24
Description	Paternally expressed 3 (HGNC Symbol)
Entrez gene summary	In human, ZIM2 and PEG3 are treated as two distinct genes though they share multiple 5' exons and a common promoter and both genes are paternally expressed (PMID:15203203). Alternative splicing events connect their shared 5' exons either with the remaining 4 exons unique to ZIM2, or with the remaining 2 exons unique to PEG3. In contrast, in other mammals ZIM2 does not undergo imprinting and, in mouse, cow, and likely other mammals as well, the ZIM2 and PEG3 genes do not share exons. Human PEG3 protein belongs to the Kruppel C2H2-type zinc finger protein family. PEG3 may play a role in cell proliferation and p53-mediated apoptosis. PEG3 has also shown tumor suppressor activity and tumorigenesis in glioma and ovarian cells. Alternative splicing of this PEG3 gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2009]
Chromosome	19
Cytoband	q13.43
Chromosome location (bp)	56810083 - 56840728
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000198300 (version 83.38)
Entrez gene	5178
UniProt	Q9GZU2 (UniProt - Evidence at protein level)
neXtProt	NX_Q9GZU2
Antibodypedia	PEG3 antibodies

PROTEIN BROWSER

PEG3-001	PEG3-002	PEG3-003	PEG3-004	PEG3-005	PEG3-006	PEG3-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PEG3-001 ENSP00000472395 ENST00000599534	Q9GZU2 [Direct mapping] Paternally-expressed gene 3 protein Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Ezkurdia et al 2014) Show all	GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0003676 [nucleic acid binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006915 [apoptotic process] GO:0046872 [metal ion binding] Show all	1588 aa 180.8 kDa	No	0
PEG3-002 ENSP00000469486 ENST00000599577	Q9GZU2 [Direct mapping] Paternally-expressed gene 3 protein Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Ezkurdia et al 2014) Show all	GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0003676 [nucleic acid binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006915 [apoptotic process] GO:0046872 [metal ion binding] Show all	1588 aa 180.8 kDa	No	0
PEG3-003 ENSP00000326581 ENST00000326441	Q9GZU2 [Direct mapping] Paternally-expressed gene 3 protein Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0003676 [nucleic acid binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006915 [apoptotic process] GO:0010468 [regulation of gene expression] GO:0046872 [metal ion binding] Show all	1588 aa 180.8 kDa	No	0
PEG3-004 ENSP00000473190 ENST00000598410	Q9GZU2 [Direct mapping] Paternally-expressed gene 3 protein Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0003676 [nucleic acid binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006915 [apoptotic process] GO:0046872 [metal ion binding] Show all	1464 aa 166.1 kDa	No	0
PEG3-005 ENSP00000472402 ENST00000593695	Q9GZU2 [Direct mapping] Paternally-expressed gene 3 protein Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0003676 [nucleic acid binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006915 [apoptotic process] GO:0046872 [metal ion binding] Show all	1462 aa 166 kDa	No	0
PEG3-006 ENSP00000470467 ENST00000600833	M0QZD4 [Direct mapping] Paternally-expressed gene 3 protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0003676 [nucleic acid binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0046872 [metal ion binding] Show all	395 aa 45.7 kDa	No	0
PEG3-009 ENSP00000469144 ENST00000594389	M0QXG1 [Direct mapping] Paternally-expressed gene 3 protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] Show all	36 aa 4 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.