Cell atlas - HYLS1 - The Human Protein Atlas

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HYLS1

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Plasma membrane

Human cell
	Cytosol
	Plasma Membrane

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GENERAL INFORMATION
Gene name	HYLS1
Gene description	Hydrolethalus syndrome 1
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the plasma membrane & cytosol.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Plasma membrane (approved), Cytosol (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA041210
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the plasma membrane & cytosol.

Main location

Plasma membrane (approved), Cytosol (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA041210	A-431	Plasma membrane
	HPA041210	A-431	Cytosol
	HPA041210	U-2 OS	Plasma membrane
	HPA041210	U-2 OS	Cytosol
	HPA041210	U-251 MG	Plasma membrane
	HPA041210	U-251 MG	Cytosol

GENE INFORMATION
Gene name	HYLS1 (HGNC Symbol)
Synonyms	FLJ32915
Description	Hydrolethalus syndrome 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein localized to the cytoplasm. Mutations in this gene are associated with hydrolethalus syndrome. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Oct 2008]
Chromosome	11
Cytoband	q24.2
Chromosome location (bp)	125883614 - 125900648
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000198331 (version 83.38)
Entrez gene	219844
UniProt	Q96M11 (UniProt - Evidence at protein level)
neXtProt	NX_Q96M11
Antibodypedia	HYLS1 antibodies

PROTEIN BROWSER

HYLS1-001	HYLS1-002	HYLS1-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HYLS1-001 ENSP00000348815 ENST00000356438	Q96M11 [Direct mapping] Hydrolethalus syndrome protein 1 A0A024R3K0 [Target identity:100%; Query identity:100%] Hydrolethalus syndrome 1, isoform CRA_a Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005813 [centrosome] GO:0005886 [plasma membrane] Show all	299 aa 34.4 kDa	No	0
HYLS1-002 ENSP00000414884 ENST00000425380	Q96M11 [Direct mapping] Hydrolethalus syndrome protein 1 A0A024R3K0 [Target identity:100%; Query identity:100%] Hydrolethalus syndrome 1, isoform CRA_a Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005813 [centrosome] GO:0005886 [plasma membrane] Show all	299 aa 34.4 kDa	No	0
HYLS1-003 ENSP00000436833 ENST00000526028	Q96M11 [Direct mapping] Hydrolethalus syndrome protein 1 A0A024R3K0 [Target identity:100%; Query identity:100%] Hydrolethalus syndrome 1, isoform CRA_a Show all	Predicted intracellular proteins Disease related genes Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005813 [centrosome] GO:0005886 [plasma membrane] Show all	299 aa 34.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.