Cell atlas - SPRED2 - The Human Protein Atlas

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SPRED2

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleoplasm

Human cell
	Cytosol
	Nucleoplasm

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GENERAL INFORMATION
Gene name	SPRED2
Gene description	Sprouty-related, EVH1 domain containing 2
Protein class	Plasma proteins Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm. In addition localized to the cytosol.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (uncertain)
Additional location	In addition localized to the Cytosol (supported)

DATA RELIABILITY
Reliability score	Uncertain based on 1 antibody. HPA038256
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm. In addition localized to the cytosol.

Main location

Nucleoplasm (uncertain)

Additional location

Cytosol (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA038256	CACO-2	Nucleoplasm
	HPA038256	CACO-2	Cytosol
	HPA038256	U-2 OS	Nucleoplasm
	HPA038256	U-2 OS	Cytosol
	HPA038256	U-251 MG	Nucleoplasm
	HPA038256	U-251 MG	Cytosol

GENE INFORMATION
Gene name	SPRED2 (HGNC Symbol)
Synonyms	FLJ21897, FLJ31917, Spred-2
Description	Sprouty-related, EVH1 domain containing 2 (HGNC Symbol)
Entrez gene summary	SPRED2 is a member of the Sprouty (see SPRY1; MIM 602465)/SPRED family of proteins that regulate growth factor-induced activation of the MAP kinase cascade (see MAPK1; MIM 176948) (Nonami et al., 2004 [PubMed 15465815]).[supplied by OMIM, Mar 2008]
Chromosome	2
Cytoband	p14
Chromosome location (bp)	65310851 - 65432637
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000198369 (version 83.38)
Entrez gene	200734
UniProt	Q7Z698 (UniProt - Evidence at protein level)
neXtProt	NX_Q7Z698
Antibodypedia	SPRED2 antibodies

PROTEIN BROWSER

SPRED2-001	SPRED2-002	SPRED2-005	SPRED2-006	SPRED2-007	SPRED2-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SPRED2-001 ENSP00000348753 ENST00000356388	Q7Z698 [Direct mapping] Sprouty-related, EVH1 domain-containing protein 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000188 [inactivation of MAPK activity] GO:0005173 [stem cell factor receptor binding] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0007275 [multicellular organismal development] GO:0009966 [regulation of signal transduction] GO:0010801 [negative regulation of peptidyl-threonine phosphorylation] GO:0016020 [membrane] GO:0019901 [protein kinase binding] GO:0030291 [protein serine/threonine kinase inhibitor activity] GO:0030658 [transport vesicle membrane] GO:0031410 [cytoplasmic vesicle] GO:0043517 [positive regulation of DNA damage response, signal transduction by p53 class mediator] GO:0090311 [regulation of protein deacetylation] Show all	418 aa 47.6 kDa	No	1
SPRED2-002 ENSP00000407627 ENST00000421087	H7C2T4 [Direct mapping] Sprouty-related, EVH1 domain-containing protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0007275 [multicellular organismal development] GO:0009966 [regulation of signal transduction] GO:0016020 [membrane] Show all	233 aa 27 kDa	No	0
SPRED2-005 ENSP00000393148 ENST00000427238	H7C065 [Direct mapping] Sprouty-related, EVH1 domain-containing protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		47 aa 5.4 kDa	No	0
SPRED2-006 ENSP00000390595 ENST00000452315	C9JG63 [Direct mapping] Sprouty-related, EVH1 domain-containing protein 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0007275 [multicellular organismal development] GO:0009966 [regulation of signal transduction] GO:0016020 [membrane] Show all	433 aa 49.2 kDa	Yes	1
SPRED2-007 ENSP00000406481 ENST00000440972	C9J623 [Direct mapping] Sprouty-related, EVH1 domain-containing protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		116 aa 13.1 kDa	No	0
SPRED2-008 ENSP00000393697 ENST00000443619	Q7Z698 [Direct mapping] Sprouty-related, EVH1 domain-containing protein 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000188 [inactivation of MAPK activity] GO:0005173 [stem cell factor receptor binding] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0007275 [multicellular organismal development] GO:0009966 [regulation of signal transduction] GO:0010801 [negative regulation of peptidyl-threonine phosphorylation] GO:0016020 [membrane] GO:0019901 [protein kinase binding] GO:0030291 [protein serine/threonine kinase inhibitor activity] GO:0030658 [transport vesicle membrane] GO:0043517 [positive regulation of DNA damage response, signal transduction by p53 class mediator] GO:0090311 [regulation of protein deacetylation] Show all	415 aa 47 kDa	No	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.