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GFPT1

GENERAL INFORMATION

Gene name

 GFPT1

Gene description

 Glutamine--fructose-6-phosphate transaminase 1

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

DATA RELIABILITY

Reliability score

 Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 GFPT1 (HGNC Symbol)

Synonyms

 GFA, GFAT, GFAT1, GFPT

Description

 Glutamine--fructose-6-phosphate transaminase 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes the first and rate-limiting enzyme of the hexosamine pathway and controls the flux of glucose into the hexosamine pathway. The product of this gene catalyzes the formation of glucosamine 6-phosphate. [provided by RefSeq, Sep 2008]

Chromosome

 2

Cytoband

 p13.3

Chromosome location (bp)

 69319769 - 69387254

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000198380 (version 83.38)

Entrez gene

 2673

UniProt

 Q06210 (UniProt - Evidence at protein level)

neXtProt

 NX_Q06210

Antibodypedia

 GFPT1 antibodies

PROTEIN BROWSER
GFPT1-001
GFPT1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GFPT1-001
ENSP00000354347
ENST00000361060
Q06210 [Direct mapping]
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004360 [glutamine-fructose-6-phosphate transaminase (isomerizing) activity]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006002 [fructose 6-phosphate metabolic process]
GO:0006047 [UDP-N-acetylglucosamine metabolic process]
GO:0006048 [UDP-N-acetylglucosamine biosynthetic process]
GO:0006112 [energy reserve metabolic process]
GO:0006487 [protein N-linked glycosylation]
GO:0006488 [dolichol-linked oligosaccharide biosynthetic process]
GO:0006541 [glutamine metabolic process]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0030246 [carbohydrate binding]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0032922 [circadian regulation of gene expression]
GO:0036498 [IRE1-mediated unfolded protein response]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0070062 [extracellular exosome]
GO:1901137 [carbohydrate derivative biosynthetic process]
Show all
 681 aa
76.8 kDa 		No 2
GFPT1-201
ENSP00000349860
ENST00000357308
Q06210 [Direct mapping]
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1
Show all
Enzymes
   ENZYME proteins
   Transferases
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004360 [glutamine-fructose-6-phosphate transaminase (isomerizing) activity]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006002 [fructose 6-phosphate metabolic process]
GO:0006042 [glucosamine biosynthetic process]
GO:0006047 [UDP-N-acetylglucosamine metabolic process]
GO:0006048 [UDP-N-acetylglucosamine biosynthetic process]
GO:0006112 [energy reserve metabolic process]
GO:0006487 [protein N-linked glycosylation]
GO:0006488 [dolichol-linked oligosaccharide biosynthetic process]
GO:0006541 [glutamine metabolic process]
GO:0009744 [response to sucrose]
GO:0016597 [amino acid binding]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0030246 [carbohydrate binding]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0032868 [response to insulin]
GO:0032869 [cellular response to insulin stimulus]
GO:0032922 [circadian regulation of gene expression]
GO:0036498 [IRE1-mediated unfolded protein response]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0045719 [negative regulation of glycogen biosynthetic process]
GO:0051289 [protein homotetramerization]
GO:0070062 [extracellular exosome]
GO:1901137 [carbohydrate derivative biosynthetic process]
Show all
 699 aa
78.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.