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ITSN2

CANCER ATLAS

Gene description

 Intersectin 2

Protein class

 Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA036475

GENE INFORMATION

Gene name

 ITSN2 (HGNC Symbol)

Synonyms

 KIAA1256, PRO2015, SH3D1B, SH3P18, SWA, SWAP

Description

 Intersectin 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a cytoplasmic protein which contains SH3 domains. This protein is a member of a family of proteins involved in clathrin-mediated endocytosis. Intersectin 2 is thought to regulate the formation of clathrin-coated vesicles and also may function in the induction of T cell antigen receptor (TCR) endocytosis. Alternatively spliced transcript variants have been found for this gene that encode three distinct isoforms. Additional variants have been found but their full length nature has not been determined. [provided by RefSeq, Jul 2008]

Chromosome

 2

Cytoband

 p23.3

Chromosome location (bp)

 24202864 - 24360714

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000198399 (version 83.38)

Entrez gene

 50618

UniProt

 Q9NZM3 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NZM3

Antibodypedia

 ITSN2 antibodies

PROTEIN BROWSER
ITSN2-001
ITSN2-002
ITSN2-003
ITSN2-004
ITSN2-008
ITSN2-012
ITSN2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ITSN2-001
ENSP00000347244
ENST00000355123
Q9NZM3 [Direct mapping]
Intersectin-2
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005070 [SH3/SH2 adaptor activity]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0006897 [endocytosis]
GO:0009967 [positive regulation of signal transduction]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0043547 [positive regulation of GTPase activity]
GO:0070062 [extracellular exosome]
GO:1903861 [positive regulation of dendrite extension]
Show all
 1697 aa
193.5 kDa 		No 0
ITSN2-002
ENSP00000354561
ENST00000361999
Q9NZM3 [Direct mapping]
Intersectin-2
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005070 [SH3/SH2 adaptor activity]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0006897 [endocytosis]
GO:0009967 [positive regulation of signal transduction]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0043547 [positive regulation of GTPase activity]
GO:0070062 [extracellular exosome]
GO:1903861 [positive regulation of dendrite extension]
Show all
 1670 aa
190.5 kDa 		No 0
ITSN2-003
ENSP00000391224
ENST00000412011
E7EPJ2 [Direct mapping]
Intersectin-2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0006897 [endocytosis]
Show all
 609 aa
69 kDa 		No 0
ITSN2-004
ENSP00000384499
ENST00000406921
Q9NZM3 [Direct mapping]
Intersectin-2
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005070 [SH3/SH2 adaptor activity]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0006897 [endocytosis]
GO:0009967 [positive regulation of signal transduction]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0043547 [positive regulation of GTPase activity]
GO:0070062 [extracellular exosome]
GO:1903861 [positive regulation of dendrite extension]
Show all
 1249 aa
141.8 kDa 		No 0
ITSN2-008
ENSP00000389013
ENST00000416160
H7BZD4 [Direct mapping]
Intersectin-2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0006897 [endocytosis]
Show all
 120 aa
13.3 kDa 		No 0
ITSN2-012
ENSP00000391715
ENST00000443927
F8W719 [Direct mapping]
Intersectin-2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0006897 [endocytosis]
Show all
 184 aa
19.8 kDa 		No 0
ITSN2-201
ENSP00000479408
ENST00000622089
A0A087WVF7 [Direct mapping]
Intersectin-2
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0006897 [endocytosis]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0043547 [positive regulation of GTPase activity]
Show all
 1680 aa
191.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.