Expression of MGEA5 in cancer - Summary

CANCER ATLAS

Gene description

Meningioma expressed antigen 5 (hyaluronidase)

Protein class

Enzymes, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA036141

GENE INFORMATION
Gene name	MGEA5 (HGNC Symbol)
Synonyms	MEA5, NCOAT, OGA
Description	Meningioma expressed antigen 5 (hyaluronidase) (HGNC Symbol)
Entrez gene summary	The dynamic modification of cytoplasmic and nuclear proteins by O-linked N-acetylglucosamine (O-GlcNAc) addition and removal on serine and threonine residues is catalyzed by OGT (MIM 300255), which adds O-GlcNAc, and MGEA5, a glycosidase that removes O-GlcNAc modifications (Gao et al., 2001 [PubMed 11148210]).[supplied by OMIM, Mar 2008]
Chromosome	10
Cytoband	q24.32
Chromosome location (bp)	101784443 - 101818465
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000198408 (version 83.38)
Entrez gene	10724
UniProt	O60502 (UniProt - Evidence at protein level)
neXtProt	NX_O60502
Antibodypedia	MGEA5 antibodies

PROTEIN BROWSER

MGEA5-002	MGEA5-003	MGEA5-004	MGEA5-005	MGEA5-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MGEA5-002 ENSP00000414235 ENST00000429860	H7C3X0 [Direct mapping] Protein O-GlcNAcase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		256 aa 29.7 kDa	No	0
MGEA5-003 ENSP00000354850 ENST00000361464	O60502 [Direct mapping] Protein O-GlcNAcase Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004415 [hyalurononglucosaminidase activity] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0006044 [N-acetylglucosamine metabolic process] GO:0006516 [glycoprotein catabolic process] GO:0006517 [protein deglycosylation] GO:0016020 [membrane] GO:0016231 [beta-N-acetylglucosaminidase activity] Show all	916 aa 102.9 kDa	No	0
MGEA5-004 ENSP00000350445 ENST00000357797	O60502 [Direct mapping] Protein O-GlcNAcase Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004415 [hyalurononglucosaminidase activity] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0006044 [N-acetylglucosamine metabolic process] GO:0006516 [glycoprotein catabolic process] GO:0006517 [protein deglycosylation] GO:0016020 [membrane] GO:0016231 [beta-N-acetylglucosaminidase activity] Show all	849 aa 95.3 kDa	No	0
MGEA5-005 ENSP00000359112 ENST00000370094	O60502 [Direct mapping] Protein O-GlcNAcase Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004415 [hyalurononglucosaminidase activity] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0006044 [N-acetylglucosamine metabolic process] GO:0006516 [glycoprotein catabolic process] GO:0006517 [protein deglycosylation] GO:0016020 [membrane] GO:0016231 [beta-N-acetylglucosaminidase activity] Show all	677 aa 76.2 kDa	No	0
MGEA5-201 ENSP00000409973 ENST00000439817	O60502 [Direct mapping] Protein O-GlcNAcase Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004415 [hyalurononglucosaminidase activity] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0006044 [N-acetylglucosamine metabolic process] GO:0006516 [glycoprotein catabolic process] GO:0006517 [protein deglycosylation] GO:0016020 [membrane] GO:0016231 [beta-N-acetylglucosaminidase activity] Show all	863 aa 96.9 kDa	No	0