Tissue expression of TPM2 - Summary - The Human Protein Atlas

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TPM2

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	TPM2
Gene description	Tropomyosin 2 (beta)
Protein class	Cancer-related genes Disease related genes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enriched (skeletal muscle)
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Expression in several tissues, most abundant in skeletal, heart and smooth muscle.

DATA RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Caution, targets protein from more than one gene. Pending external verification.
Reliability score	Approved based on 2 antibodies. HPA047089 , HPA053624
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

Skeletal muscle

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (skeletal muscle)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	TPM2 (HGNC Symbol)
Synonyms	AMCD1, DA1, NEM4
Description	Tropomyosin 2 (beta) (HGNC Symbol)
Entrez gene summary	This gene encodes beta-tropomyosin, a member of the actin filament binding protein family, and mainly expressed in slow, type 1 muscle fibers. Mutations in this gene can alter the expression of other sarcomeric tropomyosin proteins, and cause cap disease, nemaline myopathy and distal arthrogryposis syndromes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2009]
Chromosome	9
Cytoband	p13.3
Chromosome location (bp)	35681992 - 35691020
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000198467 (version 83.38)
Entrez gene	7169
UniProt	P07951 (UniProt - Evidence at protein level)
neXtProt	NX_P07951
Antibodypedia	TPM2 antibodies

PROTEIN BROWSER

TPM2-001	TPM2-002	TPM2-005	TPM2-006	TPM2-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TPM2-001 ENSP00000367542 ENST00000378292	P07951 [Direct mapping] Tropomyosin beta chain V9HW25 [Target identity:100%; Query identity:100%] Epididymis secretory protein Li 273 Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005862 [muscle thin filament tropomyosin] GO:0006936 [muscle contraction] GO:0008307 [structural constituent of muscle] GO:0030049 [muscle filament sliding] GO:0043462 [regulation of ATPase activity] Show all	284 aa 33 kDa	No	0
TPM2-002 ENSP00000354219 ENST00000360958	P07951 [Direct mapping] Tropomyosin beta chain Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0005829 [cytosol] GO:0005862 [muscle thin filament tropomyosin] GO:0006936 [muscle contraction] GO:0008307 [structural constituent of muscle] GO:0030049 [muscle filament sliding] GO:0043462 [regulation of ATPase activity] Show all	284 aa 32.9 kDa	No	0
TPM2-005 ENSP00000367550 ENST00000378300	Q5TCU8 [Direct mapping] Tropomyosin beta chain Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		322 aa 36.7 kDa	No	0
TPM2-006 ENSP00000367541 ENST00000329305	Q5TCU3 [Direct mapping] Tropomyosin beta chain Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		284 aa 32.8 kDa	No	0
TPM2-008 ENSP00000475952 ENST00000607559	U3KQK2 [Direct mapping] Tropomyosin beta chain Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		111 aa 12.9 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.