Expression of ATL1 in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Atlastin GTPase 1

Protein class

Disease related genes, Predicted intracellular proteins, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA027550

GENE INFORMATION
Gene name	ATL1 (HGNC Symbol)
Synonyms	AD-FSP, FSP1, SPG3, SPG3A
Description	Atlastin GTPase 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a GTPase and a Golgi body transmembrane protein. The encoded protein can form a homotetramer and has been shown to interact with spastin and with mitogen-activated protein kinase kinase kinase kinase 4. This protein may be involved in axonal maintenance as evidenced by the fact that defects in this gene are a cause of spastic paraplegia type 3. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	14
Cytoband	q22.1
Chromosome location (bp)	50532509 - 50633068
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000198513 (version 83.38)
Entrez gene	51062
UniProt	Q8WXF7 (UniProt - Evidence at protein level)
neXtProt	NX_Q8WXF7
Antibodypedia	ATL1 antibodies

PROTEIN BROWSER

ATL1-001	ATL1-002	ATL1-005	ATL1-006	ATL1-008	ATL1-012

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ATL1-001 ENSP00000351155 ENST00000358385	Q8WXF7 [Direct mapping] Atlastin-1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000137 [Golgi cis cisterna] GO:0000139 [Golgi membrane] GO:0003924 [GTPase activity] GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005737 [cytoplasm] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005794 [Golgi apparatus] GO:0007029 [endoplasmic reticulum organization] GO:0007409 [axonogenesis] GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] GO:0030424 [axon] GO:0042802 [identical protein binding] GO:0051260 [protein homooligomerization] Show all	558 aa 63.5 kDa	No	2
ATL1-002 ENSP00000413675 ENST00000441560	Q8WXF7 [Direct mapping] Atlastin-1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000137 [Golgi cis cisterna] GO:0000139 [Golgi membrane] GO:0003924 [GTPase activity] GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005794 [Golgi apparatus] GO:0007029 [endoplasmic reticulum organization] GO:0007409 [axonogenesis] GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] GO:0030424 [axon] GO:0042802 [identical protein binding] GO:0051260 [protein homooligomerization] Show all	553 aa 63.1 kDa	No	2
ATL1-005 ENSP00000452506 ENST00000555960	G3V5T4 [Direct mapping] Atlastin-1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003924 [GTPase activity] GO:0005525 [GTP binding] GO:0008152 [metabolic process] Show all	100 aa 11.6 kDa	No	0
ATL1-006 ENSP00000450989 ENST00000553509	G3V321 [Direct mapping] Atlastin-1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		29 aa 3.5 kDa	No	0
ATL1-008 ENSP00000452074 ENST00000554886	G3V4Y8 [Direct mapping] Atlastin-1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003924 [GTPase activity] GO:0005525 [GTP binding] GO:0008152 [metabolic process] Show all	75 aa 8.7 kDa	No	0
ATL1-012 ENSP00000451015 ENST00000557735	G3V334 [Direct mapping] Atlastin-1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003924 [GTPase activity] GO:0005525 [GTP binding] GO:0008152 [metabolic process] Show all	47 aa 5.6 kDa	No	0