Tissue expression of CNGA1 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	CNGA1
Gene description	Cyclic nucleotide gated channel alpha 1
Protein class	Disease related genes Potential drug targets Predicted intracellular proteins Predicted membrane proteins Transporters Voltage-gated ion channels
Predicted localization	Intracellular,Membrane
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Mixed
GTEx:	Mixed
FANTOM5:	Mixed

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Mixed
GTEx dataset Organ Expression Alphabetical RNA tissue category: Mixed
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Mixed

GENE INFORMATION
Gene name	CNGA1 (HGNC Symbol)
Synonyms	CNCG, CNCG1, CNG1, RCNC1, RCNCa, RP49
Description	Cyclic nucleotide gated channel alpha 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is involved in phototransduction. Along with another protein, the encoded protein forms a cGMP-gated cation channel in the plasma membrane, allowing depolarization of rod photoreceptors. This represents the last step in the phototransduction pathway. Defects in this gene are a cause of retinitis pigmentosa autosomal recessive (ARRP) disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
Chromosome	4
Cytoband	p12
Chromosome location (bp)	47935977 - 48016672
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000198515 (version 83.38)
Entrez gene	1259
UniProt	P29973 (UniProt - Evidence at protein level)
neXtProt	NX_P29973
Antibodypedia	CNGA1 antibodies

PROTEIN BROWSER

CNGA1-001	CNGA1-005	CNGA1-006	CNGA1-007	CNGA1-008	CNGA1-009	CNGA1-201	CNGA1-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CNGA1-001 ENSP00000384264 ENST00000402813	P29973 [Direct mapping] cGMP-gated cation channel alpha-1 Show all	Transporters Transporter channels and pores Voltage-gated ion channels Cyclic Nucleotide-Regulated Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Show all	GO:0001750 [photoreceptor outer segment] GO:0005216 [ion channel activity] GO:0005222 [intracellular cAMP activated cation channel activity] GO:0005223 [intracellular cGMP activated cation channel activity] GO:0005249 [voltage-gated potassium channel activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006811 [ion transport] GO:0007601 [visual perception] GO:0007603 [phototransduction, visible light] GO:0016020 [membrane] GO:0016056 [rhodopsin mediated signaling pathway] GO:0022400 [regulation of rhodopsin mediated signaling pathway] GO:0030553 [cGMP binding] GO:0042391 [regulation of membrane potential] GO:0042622 [photoreceptor outer segment membrane] GO:0055085 [transmembrane transport] GO:0071805 [potassium ion transmembrane transport] Show all	759 aa 86.9 kDa	No	5
CNGA1-005 ENSP00000423327 ENST00000513178	D6R978 [Direct mapping] cGMP-gated cation channel alpha-1 Show all	Predicted intracellular proteins Show all	GO:0005222 [intracellular cAMP activated cation channel activity] GO:0005223 [intracellular cGMP activated cation channel activity] GO:0005249 [voltage-gated potassium channel activity] GO:0030553 [cGMP binding] GO:0042391 [regulation of membrane potential] GO:0071805 [potassium ion transmembrane transport] Show all	99 aa 11 kDa	No	0
CNGA1-006 ENSP00000426862 ENST00000514170	P29973 [Direct mapping] cGMP-gated cation channel alpha-1 A0A024R9X3 [Target identity:100%; Query identity:100%] Cyclic nucleotide gated channel alpha 1, isoform CRA_a Show all	Transporters Transporter channels and pores Voltage-gated ion channels Cyclic Nucleotide-Regulated Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Disease related genes Potential drug targets Show all	GO:0005216 [ion channel activity] GO:0005222 [intracellular cAMP activated cation channel activity] GO:0005223 [intracellular cGMP activated cation channel activity] GO:0005249 [voltage-gated potassium channel activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006811 [ion transport] GO:0007601 [visual perception] GO:0007603 [phototransduction, visible light] GO:0016020 [membrane] GO:0016056 [rhodopsin mediated signaling pathway] GO:0022400 [regulation of rhodopsin mediated signaling pathway] GO:0030553 [cGMP binding] GO:0042391 [regulation of membrane potential] GO:0055085 [transmembrane transport] GO:0071805 [potassium ion transmembrane transport] Show all	690 aa 79.6 kDa	No	5
CNGA1-007 ENSP00000389881 ENST00000420489	P29973 [Direct mapping] cGMP-gated cation channel alpha-1 A0A024R9X3 [Target identity:100%; Query identity:100%] Cyclic nucleotide gated channel alpha 1, isoform CRA_a Show all	Transporters Transporter channels and pores Voltage-gated ion channels Cyclic Nucleotide-Regulated Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Show all	GO:0005216 [ion channel activity] GO:0005222 [intracellular cAMP activated cation channel activity] GO:0005223 [intracellular cGMP activated cation channel activity] GO:0005249 [voltage-gated potassium channel activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006811 [ion transport] GO:0007601 [visual perception] GO:0007603 [phototransduction, visible light] GO:0016020 [membrane] GO:0016056 [rhodopsin mediated signaling pathway] GO:0022400 [regulation of rhodopsin mediated signaling pathway] GO:0030553 [cGMP binding] GO:0042391 [regulation of membrane potential] GO:0055085 [transmembrane transport] GO:0071805 [potassium ion transmembrane transport] Show all	690 aa 79.6 kDa	No	5
CNGA1-008 ENSP00000423721 ENST00000504722	D6RCF1 [Direct mapping] cGMP-gated cation channel alpha-1 Show all	Predicted intracellular proteins Show all	GO:0005222 [intracellular cAMP activated cation channel activity] GO:0005223 [intracellular cGMP activated cation channel activity] GO:0005249 [voltage-gated potassium channel activity] GO:0030553 [cGMP binding] GO:0042391 [regulation of membrane potential] GO:0071805 [potassium ion transmembrane transport] Show all	128 aa 14.5 kDa	No	0
CNGA1-009 ENSP00000421110 ENST00000514520	D6R978 [Direct mapping] cGMP-gated cation channel alpha-1 Show all	Predicted intracellular proteins Show all	GO:0005222 [intracellular cAMP activated cation channel activity] GO:0005223 [intracellular cGMP activated cation channel activity] GO:0005249 [voltage-gated potassium channel activity] GO:0030553 [cGMP binding] GO:0042391 [regulation of membrane potential] GO:0071805 [potassium ion transmembrane transport] Show all	99 aa 11 kDa	No	0
CNGA1-201 ENSP00000351320 ENST00000358519	P29973 [Direct mapping] cGMP-gated cation channel alpha-1 A0A024R9X3 [Target identity:100%; Query identity:100%] Cyclic nucleotide gated channel alpha 1, isoform CRA_a Show all	Transporters Transporter channels and pores Voltage-gated ion channels Cyclic Nucleotide-Regulated Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Disease related genes Potential drug targets Show all	GO:0005216 [ion channel activity] GO:0005222 [intracellular cAMP activated cation channel activity] GO:0005223 [intracellular cGMP activated cation channel activity] GO:0005249 [voltage-gated potassium channel activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006811 [ion transport] GO:0007601 [visual perception] GO:0007603 [phototransduction, visible light] GO:0016020 [membrane] GO:0016056 [rhodopsin mediated signaling pathway] GO:0022400 [regulation of rhodopsin mediated signaling pathway] GO:0030553 [cGMP binding] GO:0042391 [regulation of membrane potential] GO:0055085 [transmembrane transport] GO:0071805 [potassium ion transmembrane transport] Show all	690 aa 79.6 kDa	No	5
CNGA1-202 ENSP00000443401 ENST00000544810	P29973 [Direct mapping] cGMP-gated cation channel alpha-1 Show all	Transporters Transporter channels and pores Voltage-gated ion channels Cyclic Nucleotide-Regulated Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Disease related genes Potential drug targets Show all	GO:0005216 [ion channel activity] GO:0005222 [intracellular cAMP activated cation channel activity] GO:0005223 [intracellular cGMP activated cation channel activity] GO:0005249 [voltage-gated potassium channel activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006811 [ion transport] GO:0007601 [visual perception] GO:0007603 [phototransduction, visible light] GO:0016020 [membrane] GO:0016056 [rhodopsin mediated signaling pathway] GO:0022400 [regulation of rhodopsin mediated signaling pathway] GO:0030553 [cGMP binding] GO:0042391 [regulation of membrane potential] GO:0055085 [transmembrane transport] GO:0071805 [potassium ion transmembrane transport] Show all	759 aa 86.9 kDa	No	5