We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure. [provided by RefSeq, Jul 2008]
Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014)
Show all
GO:0002026 [regulation of the force of heart contraction] GO:0004857 [enzyme inhibitor activity] GO:0005246 [calcium channel regulator activity] GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005783 [endoplasmic reticulum] GO:0005829 [cytosol] GO:0006816 [calcium ion transport] GO:0006874 [cellular calcium ion homeostasis] GO:0007219 [Notch signaling pathway] GO:0008015 [blood circulation] GO:0008016 [regulation of heart contraction] GO:0010043 [response to zinc ion] GO:0010459 [negative regulation of heart rate] GO:0010880 [regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum] GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion] GO:0016020 [membrane] GO:0016529 [sarcoplasmic reticulum] GO:0031966 [mitochondrial membrane] GO:0031982 [vesicle] GO:0032780 [negative regulation of ATPase activity] GO:0032868 [response to insulin] GO:0033017 [sarcoplasmic reticulum membrane] GO:0033574 [response to testosterone] GO:0042030 [ATPase inhibitor activity] GO:0042802 [identical protein binding] GO:0043086 [negative regulation of catalytic activity] GO:0043234 [protein complex] GO:0045822 [negative regulation of heart contraction] GO:0048471 [perinuclear region of cytoplasm] GO:0048738 [cardiac muscle tissue development] GO:0051117 [ATPase binding] GO:0051260 [protein homooligomerization] GO:0051480 [cytosolic calcium ion homeostasis] GO:0051924 [regulation of calcium ion transport] GO:0051926 [negative regulation of calcium ion transport] GO:0055119 [relaxation of cardiac muscle] GO:0060314 [regulation of ryanodine-sensitive calcium-release channel activity] GO:0086004 [regulation of cardiac muscle cell contraction] GO:0086023 [adrenergic receptor signaling pathway involved in heart process] GO:0086036 [regulation of cardiac muscle cell membrane potential] GO:0086092 [regulation of the force of heart contraction by cardiac conduction] GO:0090279 [regulation of calcium ion import] GO:0090281 [negative regulation of calcium ion import] GO:0090534 [calcium ion-transporting ATPase complex] GO:1901020 [negative regulation of calcium ion transmembrane transporter activity] GO:1901077 [regulation of relaxation of muscle] GO:1901877 [negative regulation of calcium ion binding] GO:1901894 [regulation of calcium-transporting ATPase activity] GO:1901895 [negative regulation of calcium-transporting ATPase activity] GO:1901897 [regulation of relaxation of cardiac muscle] GO:1902081 [negative regulation of calcium ion import into sarcoplasmic reticulum]
