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DDX39B

GENERAL INFORMATION

Gene name

 DDX39B

Gene description

 DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins
Transporters

Predicted localization

 Intracellular

Number of transcripts

 14
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General nuclear expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA055334 , HPA058450 , CAB034012
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Ovary

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 DDX39B (HGNC Symbol)

Synonyms

 BAT1, D6S81E, UAP56

Description

 DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the DEAD box family of RNA-dependent ATPases that mediate ATP hydrolysis during pre-mRNA splicing. The encoded protein is an essential splicing factor required for association of U2 small nuclear ribonucleoprotein with pre-mRNA, and it also plays an important role in mRNA export from the nucleus to the cytoplasm. This gene belongs to a cluster of genes localized in the vicinity of the genes encoding tumor necrosis factor alpha and tumor necrosis factor beta. These genes are all within the human major histocompatibility complex class III region. Mutations in this gene may be associated with rheumatoid arthritis. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on both chromosomes 6 and 11. Read-through transcription also occurs between this gene and the upstream ATP6V1G2 (ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2) gene. [provided by RefSeq, Feb 2011]

Chromosome

 6

Cytoband

 p21.33

Chromosome location (bp)

 31530219 - 31542448

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000198563 (version 83.38)

Entrez gene

 7919

UniProt

 Q13838 (UniProt - Evidence at protein level)

neXtProt

 NX_Q13838

Antibodypedia

 DDX39B antibodies

PROTEIN BROWSER
«
DDX39B-001
DDX39B-002
DDX39B-006
DDX39B-009
DDX39B-010
DDX39B-011
DDX39B-012
DDX39B-013
DDX39B-014
DDX39B-016
DDX39B-017
DDX39B-018
DDX39B-019
DDX39B-020
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DDX39B-001
ENSP00000379475
ENST00000396172
Q13838 [Direct mapping]
Spliceosome RNA helicase DDX39B
A0A024RCM3 [Target identity:100%; Query identity:100%]
HCG2005638, isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Transporters
   Primary Active Transporters
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000245 [spliceosomal complex assembly]
GO:0000346 [transcription export complex]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0001889 [liver development]
GO:0003676 [nucleic acid binding]
GO:0004004 [ATP-dependent RNA helicase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005681 [spliceosomal complex]
GO:0005687 [U4 snRNP]
GO:0005688 [U6 snRNP]
GO:0005737 [cytoplasm]
GO:0006406 [mRNA export from nucleus]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0008186 [RNA-dependent ATPase activity]
GO:0008380 [RNA splicing]
GO:0010501 [RNA secondary structure unwinding]
GO:0016363 [nuclear matrix]
GO:0016607 [nuclear speck]
GO:0017070 [U6 snRNA binding]
GO:0030621 [U4 snRNA binding]
GO:0032403 [protein complex binding]
GO:0032786 [positive regulation of DNA-templated transcription, elongation]
GO:0043008 [ATP-dependent protein binding]
GO:0043234 [protein complex]
GO:0044822 [poly(A) RNA binding]
GO:0045727 [positive regulation of translation]
GO:0046784 [viral mRNA export from host cell nucleus]
GO:0061051 [positive regulation of cell growth involved in cardiac muscle cell development]
GO:1904707 [positive regulation of vascular smooth muscle cell proliferation]
GO:2000002 [negative regulation of DNA damage checkpoint]
GO:2000573 [positive regulation of DNA biosynthetic process]
Show all
 428 aa
49 kDa 		No 0
DDX39B-002
ENSP00000416269
ENST00000458640
Q13838 [Direct mapping]
Spliceosome RNA helicase DDX39B
A0A024RCM3 [Target identity:100%; Query identity:100%]
HCG2005638, isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Transporters
   Primary Active Transporters
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000245 [spliceosomal complex assembly]
GO:0000346 [transcription export complex]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0003676 [nucleic acid binding]
GO:0004004 [ATP-dependent RNA helicase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005681 [spliceosomal complex]
GO:0005687 [U4 snRNP]
GO:0005688 [U6 snRNP]
GO:0005737 [cytoplasm]
GO:0006406 [mRNA export from nucleus]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0008186 [RNA-dependent ATPase activity]
GO:0008380 [RNA splicing]
GO:0010501 [RNA secondary structure unwinding]
GO:0016607 [nuclear speck]
GO:0017070 [U6 snRNA binding]
GO:0030621 [U4 snRNA binding]
GO:0032786 [positive regulation of DNA-templated transcription, elongation]
GO:0043008 [ATP-dependent protein binding]
GO:0044822 [poly(A) RNA binding]
GO:0046784 [viral mRNA export from host cell nucleus]
GO:2000002 [negative regulation of DNA damage checkpoint]
Show all
 428 aa
49 kDa 		No 0
DDX39B-006
ENSP00000365347
ENST00000376177
Q5STU3 [Direct mapping]
Spliceosome RNA helicase DDX39B
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0004386 [helicase activity]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0008152 [metabolic process]
Show all
 425 aa
48.8 kDa 		No 0
DDX39B-009
ENSP00000392672
ENST00000428098
F6TRA5 [Direct mapping]
Spliceosome RNA helicase DDX39B
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0006974 [cellular response to DNA damage stimulus]
Show all
 238 aa
26.7 kDa 		No 0
DDX39B-010
ENSP00000405245
ENST00000419020
F6S2B7 [Direct mapping]
Spliceosome RNA helicase DDX39B
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0006974 [cellular response to DNA damage stimulus]
Show all
 132 aa
14.3 kDa 		No 0
DDX39B-011
ENSP00000399841
ENST00000418897
F6SXL5 [Direct mapping]
Spliceosome RNA helicase DDX39B
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0006974 [cellular response to DNA damage stimulus]
Show all
 136 aa
14.7 kDa 		No 0
DDX39B-012
ENSP00000393984
ENST00000456976
F6U6E2 [Direct mapping]
Spliceosome RNA helicase DDX39B
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0006974 [cellular response to DNA damage stimulus]
Show all
 125 aa
13.5 kDa 		No 0
DDX39B-013
ENSP00000405707
ENST00000428450
F6R6M7 [Direct mapping]
Spliceosome RNA helicase DDX39B
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   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0006974 [cellular response to DNA damage stimulus]
Show all
 197 aa
21.9 kDa 		No 0
DDX39B-014
ENSP00000416350
ENST00000456662
F6S4E6 [Direct mapping]
Spliceosome RNA helicase DDX39B
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0006974 [cellular response to DNA damage stimulus]
Show all
 231 aa
25.9 kDa 		No 0
DDX39B-016
ENSP00000409426
ENST00000449757
F6QYI9 [Direct mapping]
Spliceosome RNA helicase DDX39B
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0006974 [cellular response to DNA damage stimulus]
Show all
 187 aa
20.5 kDa 		No 0
DDX39B-017
ENSP00000399371
ENST00000427214
F6WLT2 [Direct mapping]
Spliceosome RNA helicase DDX39B
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0006974 [cellular response to DNA damage stimulus]
Show all
 289 aa
32.9 kDa 		No 0
DDX39B-018
ENSP00000410313
ENST00000419338
A0A0A0MT12 [Direct mapping]
Spliceosome RNA helicase DDX39B
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0005524 [ATP binding]
GO:0006974 [cellular response to DNA damage stimulus]
Show all
 236 aa
26.5 kDa 		No 0
DDX39B-019
ENSP00000408000
ENST00000431908
F6UJC5 [Direct mapping]
Spliceosome RNA helicase DDX39B
Show all
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0005524 [ATP binding]
GO:0006974 [cellular response to DNA damage stimulus]
Show all
 245 aa
28.3 kDa 		No 0
DDX39B-020
ENSP00000406422
ENST00000417023
H0Y400 [Direct mapping]
Spliceosome RNA helicase DDX39B
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006974 [cellular response to DNA damage stimulus]
Show all
 187 aa
21.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.