Cell atlas - MDM4 - The Human Protein Atlas

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MDM4

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS MOUSE CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleus

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	MDM4
Gene description	MDM4, p53 regulator
Protein class	Cancer-related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	12
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleus.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (supported)
Mouse	Localized to the Nuclear bodies, Cytosol in mouse cells.

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA048821
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleus.

Main location

Nucleus (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA048821	A-431	Nucleoplasm
	HPA048821	U-2 OS	Nucleus
	HPA048821	U-251 MG	Nucleoplasm

MOUSE CELLS

Main location

Nuclear bodies, Cytosol

Mouse gene

ENSMUSG00000054387 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA048821	NIH 3T3	Nuclear bodies
	HPA048821	NIH 3T3	Cytosol

GENE INFORMATION
Gene name	MDM4 (HGNC Symbol)
Synonyms	HDMX, MDMX
Description	MDM4, p53 regulator (HGNC Symbol)
Entrez gene summary	This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latter's degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Feb 2011]
Chromosome	1
Cytoband	q32.1
Chromosome location (bp)	204516379 - 204558120
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000198625 (version 83.38)
Entrez gene	4194
UniProt	O15151 (UniProt - Evidence at protein level)
neXtProt	NX_O15151
Antibodypedia	MDM4 antibodies

PROTEIN BROWSER

MDM4-001	MDM4-006	MDM4-007	MDM4-009	MDM4-201	MDM4-202	MDM4-203	MDM4-204	MDM4-205	MDM4-206	MDM4-207	MDM4-208

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MDM4-001 ENSP00000356150 ENST00000367182	O15151 [Direct mapping] Protein Mdm4 A0A024R990 [Target identity:100%; Query identity:100%] Mdm4, transformed 3T3 cell double minute 4, p53 binding protein (Mouse), isoform CRA_a Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Protein evidence (Kim et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0002027 [regulation of heart rate] GO:0003170 [heart valve development] GO:0003181 [atrioventricular valve morphogenesis] GO:0003203 [endocardial cushion morphogenesis] GO:0003281 [ventricular septum development] GO:0003283 [atrial septum development] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006461 [protein complex assembly] GO:0008270 [zinc ion binding] GO:0008283 [cell proliferation] GO:0008284 [positive regulation of cell proliferation] GO:0008285 [negative regulation of cell proliferation] GO:0019899 [enzyme binding] GO:0030330 [DNA damage response, signal transduction by p53 class mediator] GO:0042177 [negative regulation of protein catabolic process] GO:0043066 [negative regulation of apoptotic process] GO:0045023 [G0 to G1 transition] GO:0050821 [protein stabilization] GO:0071157 [negative regulation of cell cycle arrest] GO:0071456 [cellular response to hypoxia] Show all	490 aa 54.9 kDa	No	0
MDM4-006 ENSP00000356147 ENST00000367179	Q5T0Y2 [Direct mapping] Protein Mdm4 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Show all	GO:0005634 [nucleus] GO:0008270 [zinc ion binding] GO:0043066 [negative regulation of apoptotic process] GO:0071157 [negative regulation of cell cycle arrest] Show all	213 aa 24.2 kDa	No	0
MDM4-007 ENSP00000395254 ENST00000444261	Q5T0Y3 [Direct mapping] Protein Mdm4 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Show all	GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0008270 [zinc ion binding] GO:0043066 [negative regulation of apoptotic process] GO:0071157 [negative regulation of cell cycle arrest] Show all	171 aa 19.6 kDa	No	0
MDM4-009 ENSP00000356148 ENST00000367180	Q5T0Y4 [Direct mapping] Protein Mdm4 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0043066 [negative regulation of apoptotic process] GO:0071157 [negative regulation of cell cycle arrest] Show all	131 aa 14.6 kDa	No	0
MDM4-201 ENSP00000356151 ENST00000367183	O15151 [Direct mapping] Protein Mdm4 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006461 [protein complex assembly] GO:0008270 [zinc ion binding] GO:0008283 [cell proliferation] GO:0008285 [negative regulation of cell proliferation] GO:0019899 [enzyme binding] GO:0030330 [DNA damage response, signal transduction by p53 class mediator] GO:0042177 [negative regulation of protein catabolic process] GO:0043066 [negative regulation of apoptotic process] GO:0045023 [G0 to G1 transition] GO:0050821 [protein stabilization] GO:0071157 [negative regulation of cell cycle arrest] GO:0071456 [cellular response to hypoxia] Show all	164 aa 18.2 kDa	No	0
MDM4-202 ENSP00000375811 ENST00000391947	Q68DC0 [Direct mapping] MDM4 protein variant G; MDM4 protein variant Y; Protein Mdm4; Putative uncharacterized protein DKFZp781B1423; cDNA FLJ56709, highly similar to Mdm4 protein Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0043066 [negative regulation of apoptotic process] GO:0071157 [negative regulation of cell cycle arrest] Show all	140 aa 15.9 kDa	No	0
MDM4-203 ENSP00000396840 ENST00000454264	O15151 [Direct mapping] Protein Mdm4 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Protein evidence (Kim et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006461 [protein complex assembly] GO:0008270 [zinc ion binding] GO:0008283 [cell proliferation] GO:0008285 [negative regulation of cell proliferation] GO:0019899 [enzyme binding] GO:0030330 [DNA damage response, signal transduction by p53 class mediator] GO:0042177 [negative regulation of protein catabolic process] GO:0043066 [negative regulation of apoptotic process] GO:0045023 [G0 to G1 transition] GO:0050821 [protein stabilization] GO:0071157 [negative regulation of cell cycle arrest] GO:0071456 [cellular response to hypoxia] Show all	440 aa 49.5 kDa	No	0
MDM4-204 ENSP00000443816 ENST00000507825	Q68DC0 [Direct mapping] MDM4 protein variant G; MDM4 protein variant Y; Protein Mdm4; Putative uncharacterized protein DKFZp781B1423; cDNA FLJ56709, highly similar to Mdm4 protein Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0043066 [negative regulation of apoptotic process] GO:0071157 [negative regulation of cell cycle arrest] Show all	140 aa 15.9 kDa	No	0
MDM4-205 ENSP00000478080 ENST00000612738	A0A087WTR9 [Direct mapping] Protein Mdm4 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0008270 [zinc ion binding] GO:0043066 [negative regulation of apoptotic process] GO:0071157 [negative regulation of cell cycle arrest] Show all	267 aa 29.9 kDa	No	0
MDM4-206 ENSP00000482388 ENST00000614459	A0A087WZ58 [Direct mapping] Protein Mdm4 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0008270 [zinc ion binding] GO:0043066 [negative regulation of apoptotic process] GO:0071157 [negative regulation of cell cycle arrest] Show all	392 aa 44 kDa	No	0
MDM4-207 ENSP00000478581 ENST00000616250	A0A087WUE3 [Direct mapping] Protein Mdm4 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0043066 [negative regulation of apoptotic process] GO:0071157 [negative regulation of cell cycle arrest] Show all	116 aa 12.8 kDa	No	0
MDM4-208 ENSP00000482479 ENST00000621032	Q6MZR7 [Direct mapping] Protein Mdm4; Putative uncharacterized protein DKFZp686B01123 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0043066 [negative regulation of apoptotic process] GO:0071157 [negative regulation of cell cycle arrest] Show all	153 aa 17.3 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.