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Most cancer tissues showed weak to moderate cytoplasmic and membranous immunoreactivity. Lymphomas and renal cancers along with several gliomas, ovarian, lung and liver cancers were negative.
Most malignancies showed moderate cytoplasmic staining. A few cases of breast cancers showed strong immunoreactivity. Many cases of gliomas, lymphomas and renal cancers were weakly stained.
This gene encodes a member of the EF-hand calcium-binding protein family. It is one of three genes which encode an identical calcium binding protein which is one of the four subunits of phosphorylase kinase. Two pseudogenes have been identified on chromosome 7 and X. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]