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LPA

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GENERAL INFORMATION

Gene name

 LPA

Gene description

 Lipoprotein, Lp(a)

Protein class

 Candidate cardiovascular disease genes
Enzymes
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Not detected

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Not detected
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 LPA (HGNC Symbol)

Synonyms

 LP

Description

 Lipoprotein, Lp(a) (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a serine proteinase that inhibits the activity of tissue-type plasminogen activator I. The encoded protein constitutes a substantial portion of lipoprotein(a) and is proteolytically cleaved, resulting in fragments that attach to atherosclerotic lesions and promote thrombogenesis. Elevated plasma levels of this protein are linked to atherosclerosis. Depending on the individual, the encoded protein contains 2-43 copies of kringle-type domains. The allele represented here contains 15 copies of the kringle-type repeats and corresponds to that found in the reference genome sequence. [provided by RefSeq, Dec 2009]

Chromosome

 6

Cytoband

Chromosome location (bp)

 160531483 - 160664259

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000198670 (version 83.38)

Entrez gene

 4018

UniProt

 P08519 (UniProt - Evidence at protein level)

neXtProt

 NX_P08519

Antibodypedia

 LPA antibodies

PROTEIN BROWSER
LPA-001
LPA-201
LPA-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
LPA-001
ENSP00000321334
ENST00000316300
P08519 [Direct mapping]
Apolipoprotein(a)
Show all
Enzymes
   Peptidases
   Serine-type peptidases
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Candidate cardiovascular disease genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001968 [fibronectin binding]
GO:0004252 [serine-type endopeptidase activity]
GO:0004866 [endopeptidase inhibitor activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0006508 [proteolysis]
GO:0006629 [lipid metabolic process]
GO:0006869 [lipid transport]
GO:0006898 [receptor-mediated endocytosis]
GO:0008015 [blood circulation]
GO:0008201 [heparin binding]
GO:0010951 [negative regulation of endopeptidase activity]
GO:0034185 [apolipoprotein binding]
GO:0034358 [plasma lipoprotein particle]
GO:0042157 [lipoprotein metabolic process]
GO:0044281 [small molecule metabolic process]
Show all
 2040 aa
226.5 kDa 		Yes 0
LPA-201
ENSP00000395608
ENST00000447678
P08519 [Direct mapping]
Apolipoprotein(a)
Show all
Enzymes
   Peptidases
   Serine-type peptidases
Predicted intracellular proteins
Plasma proteins
Candidate cardiovascular disease genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001968 [fibronectin binding]
GO:0004252 [serine-type endopeptidase activity]
GO:0004866 [endopeptidase inhibitor activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0006508 [proteolysis]
GO:0006629 [lipid metabolic process]
GO:0006869 [lipid transport]
GO:0006898 [receptor-mediated endocytosis]
GO:0008015 [blood circulation]
GO:0008201 [heparin binding]
GO:0010951 [negative regulation of endopeptidase activity]
GO:0034185 [apolipoprotein binding]
GO:0034358 [plasma lipoprotein particle]
GO:0042157 [lipoprotein metabolic process]
GO:0044281 [small molecule metabolic process]
Show all
 613 aa
68.7 kDa 		No 0
LPA-202
ENSP00000480589
ENST00000614786
A0A087WWY0 [Direct mapping]
Apolipoprotein(a)
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 571 aa
62.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.