Cell atlas - FAN1 - The Human Protein Atlas

GENERAL INFORMATION
Gene name	FAN1
Gene description	FANCD2/FANCI-associated nuclease 1
Protein class	Disease related genes Enzymes Potential drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm. In addition localized to the cytosol & cytokinetic bridge.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (supported)
Additional location	In addition localized to the Cytokinetic bridge (uncertain), Cytosol (uncertain)
Single-cell variation	Single-cell variation in protein expression observed.
Cell cycle dependency	Cell cycle dependent expression determined by biological definition
Mouse	Localized to the Nucleoplasm in mouse cells.

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA048198
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ASSAYS

RNA expression

Human cells

Mouse cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm. In addition localized to the cytosol & cytokinetic bridge.

Main location

Nucleoplasm (supported)

Additional location

Cytokinetic bridge (uncertain), Cytosol (uncertain)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
HPA048198	A-431	Nucleoplasm
HPA048198	HeLa	Nucleoplasm
		Cytokinetic bridge	Intensity	Intensity
		Cytosol
HPA048198	U-2 OS	No staining

CELL CYCLE
Summary	Expression has cell cycle dependency according to biological definition
Intensity variation	Cytokinetic bridge

MOUSE CELLS

Main location

Nucleoplasm

Mouse gene

ENSMUSG00000033458 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA048198	NIH 3T3	Nucleoplasm

GENE INFORMATION
Gene name	FAN1 (HGNC Symbol)
Synonyms	KIAA1018, MTMR15
Description	FANCD2/FANCI-associated nuclease 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the myotubularin-related class 1 cysteine-based protein tyrosine phosphatases. The encoded protein may be catalytically inactive. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2009]
Chromosome	15
Cytoband	q13.3
Chromosome location (bp)	30903852 - 30943108
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000198690 (version 83.38)
Entrez gene	22909
UniProt	Q9Y2M0 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y2M0
Antibodypedia	FAN1 antibodies

PROTEIN BROWSER

FAN1-001	FAN1-002	FAN1-003	FAN1-004	FAN1-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FAN1-001 ENSP00000354497 ENST00000362065	Q9Y2M0 [Direct mapping] Fanconi-associated nuclease 1 Show all	Enzymes ENZYME proteins Hydrolases MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Show all	GO:0000287 [magnesium ion binding] GO:0000724 [double-strand break repair via homologous recombination] GO:0003677 [DNA binding] GO:0004528 [phosphodiesterase I activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006281 [DNA repair] GO:0006289 [nucleotide-excision repair] GO:0008409 [5'-3' exonuclease activity] GO:0016788 [hydrolase activity, acting on ester bonds] GO:0017108 [5'-flap endonuclease activity] GO:0033683 [nucleotide-excision repair, DNA incision] GO:0036297 [interstrand cross-link repair] GO:0043130 [ubiquitin binding] GO:0045171 [intercellular bridge] GO:0070336 [flap-structured DNA binding] Show all	1017 aa 114.2 kDa	No	0
FAN1-002 ENSP00000455983 ENST00000561594	Q9Y2M0 [Direct mapping] Fanconi-associated nuclease 1 Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Disease related genes Potential drug targets Show all	GO:0000287 [magnesium ion binding] GO:0000724 [double-strand break repair via homologous recombination] GO:0003677 [DNA binding] GO:0004528 [phosphodiesterase I activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006281 [DNA repair] GO:0006289 [nucleotide-excision repair] GO:0008409 [5'-3' exonuclease activity] GO:0017108 [5'-flap endonuclease activity] GO:0033683 [nucleotide-excision repair, DNA incision] GO:0036297 [interstrand cross-link repair] GO:0043130 [ubiquitin binding] GO:0045171 [intercellular bridge] GO:0070336 [flap-structured DNA binding] Show all	533 aa 59.5 kDa	No	0
FAN1-003 ENSP00000454223 ENST00000561607	Q9Y2M0 [Direct mapping] Fanconi-associated nuclease 1 Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Disease related genes Potential drug targets Show all	GO:0000287 [magnesium ion binding] GO:0000724 [double-strand break repair via homologous recombination] GO:0003677 [DNA binding] GO:0004528 [phosphodiesterase I activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006281 [DNA repair] GO:0006289 [nucleotide-excision repair] GO:0008409 [5'-3' exonuclease activity] GO:0017108 [5'-flap endonuclease activity] GO:0033683 [nucleotide-excision repair, DNA incision] GO:0036297 [interstrand cross-link repair] GO:0043130 [ubiquitin binding] GO:0045171 [intercellular bridge] GO:0070336 [flap-structured DNA binding] Show all	533 aa 59.5 kDa	No	0
FAN1-004 ENSP00000454544 ENST00000565466	Q9Y2M0 [Direct mapping] Fanconi-associated nuclease 1 Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Disease related genes Potential drug targets Show all	GO:0000287 [magnesium ion binding] GO:0000724 [double-strand break repair via homologous recombination] GO:0003677 [DNA binding] GO:0004528 [phosphodiesterase I activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006281 [DNA repair] GO:0006289 [nucleotide-excision repair] GO:0008409 [5'-3' exonuclease activity] GO:0017108 [5'-flap endonuclease activity] GO:0033683 [nucleotide-excision repair, DNA incision] GO:0036297 [interstrand cross-link repair] GO:0043130 [ubiquitin binding] GO:0045171 [intercellular bridge] GO:0070336 [flap-structured DNA binding] Show all	533 aa 59.5 kDa	No	0
FAN1-008 ENSP00000457680 ENST00000562892	H3BUK3 [Direct mapping] Fanconi-associated nuclease 1 Show all	Predicted intracellular proteins Show all		105 aa 12 kDa	No	0