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SMOC1

GENERAL INFORMATION

Gene name

 SMOC1

Gene description

 SPARC related modular calcium binding 1

Protein class

 Disease related genes
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (cerebral cortex)
GTEx:Mixed
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in testis.

DATA RELIABILITY

Data reliability
description

 Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Pending external verification.

Reliability score

 Approved based on 1 antibody.
CAB034427
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebral cortex)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 SMOC1

Synonyms

Description

 SPARC related modular calcium binding 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a multi-domain secreted protein that may have a critical role in ocular and limb development. Mutations in this gene are associated with microphthalmia and limb anomalies. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]

Chromosome

 14

Cytoband

 q24.2

Chromosome location (bp)

 69854131 - 70032366

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000198732 (version 83.38)

Entrez gene

 64093

UniProt

 Q9H4F8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9H4F8

Antibodypedia

 SMOC1 antibodies

PROTEIN BROWSER
SMOC1-001
SMOC1-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SMOC1-001
ENSP00000355110
ENST00000361956
Q9H4F8 [Direct mapping]
SPARC-related modular calcium-binding protein 1
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001654 [eye development]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005604 [basement membrane]
GO:0007165 [signal transduction]
GO:0030154 [cell differentiation]
GO:0045667 [regulation of osteoblast differentiation]
GO:0060173 [limb development]
Show all
 435 aa
48.3 kDa 		Yes 0
SMOC1-002
ENSP00000370680
ENST00000381280
Q9H4F8 [Direct mapping]
SPARC-related modular calcium-binding protein 1
A0A024R6E0 [Target identity:100%; Query identity:100%]
SPARC related modular calcium binding 1, isoform CRA_b
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001654 [eye development]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005604 [basement membrane]
GO:0007165 [signal transduction]
GO:0030154 [cell differentiation]
GO:0045667 [regulation of osteoblast differentiation]
GO:0060173 [limb development]
Show all
 434 aa
48.2 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.