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Liver, pancreatic, urothelial, lung and colorectal cancer showed moderate to strong positivity. Remaining malignancies were weakly stained or negative.
GENE INFORMATION
Gene name
F5
Synonyms
Description
Coagulation factor V (proaccelerin, labile factor) (HGNC Symbol)
Entrez gene summary
This gene encodes an essential cofactor of the blood coagulation cascade. This factor circulates in plasma, and is converted to the active form by the release of the activation peptide by thrombin during coagulation. This generates a heavy chain and a light chain which are held together by calcium ions. The activated protein is a cofactor that participates with activated coagulation factor X to activate prothrombin to thrombin. Defects in this gene result in either an autosomal recessive hemorrhagic diathesis or an autosomal dominant form of thrombophilia, which is known as activated protein C resistance. [provided by RefSeq, Oct 2008]
P12259 [Direct mapping] Coagulation factor V Coagulation factor V heavy chain Coagulation factor V light chain
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Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Biotech drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
