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MSRB1

CANCER ATLAS

Gene description

 Methionine sulfoxide reductase B1

Protein class

 Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB008650

GENE INFORMATION

Gene name

 MSRB1 (HGNC Symbol)

Synonyms

 SelR, SelX, SepR, SEPX1

Description

 Methionine sulfoxide reductase B1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein belongs to the methionine sulfoxide reductase (Msr) protein family which includes repair enzymes that reduce oxidized methionine residues in proteins. The protein encoded by this gene is expressed in a variety of adult and fetal tissues and localizes to the cell nucleus and cytosol. [provided by RefSeq, Mar 2012]

Chromosome

 16

Cytoband

 p13.3

Chromosome location (bp)

 1938210 - 1943326

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000198736 (version 83.38)

Entrez gene

 51734

UniProt

 Q9NZV6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NZV6

Antibodypedia

 MSRB1 antibodies

PROTEIN BROWSER
MSRB1-001
MSRB1-003
MSRB1-004
MSRB1-005
MSRB1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MSRB1-001
ENSP00000355084
ENST00000361871
Q9NZV6 [Direct mapping]
Methionine-R-sulfoxide reductase B1
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005575 [cellular_component]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006979 [response to oxidative stress]
GO:0008270 [zinc ion binding]
GO:0015629 [actin cytoskeleton]
GO:0030041 [actin filament polymerization]
GO:0030091 [protein repair]
GO:0033743 [peptide-methionine (R)-S-oxide reductase activity]
GO:0045087 [innate immune response]
GO:0055114 [oxidation-reduction process]
GO:0070191 [methionine-R-sulfoxide reductase activity]
Show all
 116 aa
12.8 kDa 		No 0
MSRB1-003
ENSP00000457320
ENST00000473663
H3BTT6 [Direct mapping]
Methionine-R-sulfoxide reductase B1
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Predicted intracellular proteins
Show all
 56 aa
6.1 kDa 		No 0
MSRB1-004
ENSP00000382657
ENST00000399753
A8MYR2 [Direct mapping]
Methionine-R-sulfoxide reductase B1
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0006979 [response to oxidative stress]
GO:0030091 [protein repair]
GO:0033743 [peptide-methionine (R)-S-oxide reductase activity]
GO:0055114 [oxidation-reduction process]
Show all
 226 aa
24.5 kDa 		No 0
MSRB1-005
ENSP00000456557
ENST00000564908
H3BS64 [Direct mapping]
Methionine-R-sulfoxide reductase B1
Show all
Predicted intracellular proteins
Show all
GO:0006979 [response to oxidative stress]
GO:0030091 [protein repair]
GO:0033743 [peptide-methionine (R)-S-oxide reductase activity]
GO:0055114 [oxidation-reduction process]
Show all
 151 aa
16.8 kDa 		No 0
MSRB1-201
ENSP00000480943
ENST00000622125
A0A087WXE3 [Direct mapping]
Methionine-R-sulfoxide reductase B1
Show all
Predicted intracellular proteins
Show all
GO:0006979 [response to oxidative stress]
GO:0030091 [protein repair]
GO:0033743 [peptide-methionine (R)-S-oxide reductase activity]
GO:0055114 [oxidation-reduction process]
Show all
 115 aa
12.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.