Expression of CDC42BPB in cancer - Summary

CANCER ATLAS

Gene description

CDC42 binding protein kinase beta (DMPK-like)

Protein class

Enzymes, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

STAINING SUMMARY

HPA022821

GENE INFORMATION
Gene name	CDC42BPB (HGNC Symbol)
Synonyms	KIAA1124, MRCKB
Description	CDC42 binding protein kinase beta (DMPK-like) (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the serine/threonine protein kinase family. The encoded protein contains a Cdc42/Rac-binding p21 binding domain resembling that of PAK kinase. The kinase domain of this protein is most closely related to that of myotonic dystrophy kinase-related ROK. Studies of the similar gene in rat suggested that this kinase may act as a downstream effector of Cdc42 in cytoskeletal reorganization. [provided by RefSeq, Jul 2008]
Chromosome	14
Cytoband	q32.32
Chromosome location (bp)	102932379 - 103057462
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000198752 (version 83.38)
Entrez gene	9578
UniProt	Q9Y5S2 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y5S2
Antibodypedia	CDC42BPB antibodies

PROTEIN BROWSER

CDC42BPB-001	CDC42BPB-002	CDC42BPB-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CDC42BPB-001 ENSP00000355237 ENST00000361246	Q9Y5S2 [Direct mapping] Serine/threonine-protein kinase MRCK beta A0A024R6N2 [Target identity:100%; Query identity:100%] Non-specific serine/threonine protein kinase Show all	Enzymes ENZYME proteins Transferases Kinases AGC Ser/Thr protein kinases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000287 [magnesium ion binding] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0005886 [plasma membrane] GO:0005911 [cell-cell junction] GO:0006468 [protein phosphorylation] GO:0007010 [cytoskeleton organization] GO:0007163 [establishment or maintenance of cell polarity] GO:0007165 [signal transduction] GO:0016477 [cell migration] GO:0017048 [Rho GTPase binding] GO:0030036 [actin cytoskeleton organization] GO:0031032 [actomyosin structure organization] GO:0031252 [cell leading edge] GO:0031532 [actin cytoskeleton reorganization] GO:0035556 [intracellular signal transduction] GO:0042641 [actomyosin] GO:0070062 [extracellular exosome] Show all	1711 aa 194.3 kDa	No	0
CDC42BPB-002 ENSP00000453384 ENST00000559043	H0YLY0 [Direct mapping] Serine/threonine-protein kinase MRCK beta Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004674 [protein serine/threonine kinase activity] GO:0005524 [ATP binding] GO:0005622 [intracellular] GO:0006468 [protein phosphorylation] GO:0035556 [intracellular signal transduction] GO:0046872 [metal ion binding] Show all	667 aa 74.5 kDa	No	0
CDC42BPB-006 ENSP00000489452 ENST00000558321		Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	129 aa 14.7 kDa	No	0