Tissue expression of GRIN3A - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	GRIN3A
Gene description	Glutamate receptor, ionotropic, N-methyl-D-aspartate 3A
Protein class	FDA approved drug targets Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Group enriched (cerebral cortex, cervix, uterine)
GTEx:	Tissue enhanced (hypothalamus, cerebral cortex)
FANTOM5:	Tissue enhanced (hippocampus, retina)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Group enriched (cerebral cortex, cervix, uterine)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (hypothalamus, cerebral cortex)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (hippocampus, retina)

GENE INFORMATION
Gene name	GRIN3A (HGNC Symbol)
Synonyms	GluN3A
Description	Glutamate receptor, ionotropic, N-methyl-D-aspartate 3A (HGNC Symbol)
Entrez gene summary	This gene encodes a subunit of the N-methyl-D-aspartate (NMDA) receptors, which belong to the superfamily of glutamate-regulated ion channels, and function in physiological and pathological processes in the central nervous system. This subunit shows greater than 90% identity to the corresponding subunit in rat. Studies in the knockout mouse deficient in this subunit suggest that this gene may be involved in the development of synaptic elements by modulating NMDA receptor activity. [provided by RefSeq, Jul 2008]
Chromosome	9
Cytoband	q31.1
Chromosome location (bp)	101569353 - 101738580
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000198785 (version 83.38)
Entrez gene	116443
UniProt	Q8TCU5 (UniProt - Evidence at protein level)
neXtProt	NX_Q8TCU5
Antibodypedia	GRIN3A antibodies

PROTEIN BROWSER

GRIN3A-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GRIN3A-001 ENSP00000355155 ENST00000361820	Q8TCU5 [Direct mapping] Glutamate receptor ionotropic, NMDA 3A Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Show all	GO:0004970 [ionotropic glutamate receptor activity] GO:0004972 [NMDA glutamate receptor activity] GO:0005234 [extracellular-glutamate-gated ion channel activity] GO:0005262 [calcium channel activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006816 [calcium ion transport] GO:0014069 [postsynaptic density] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016358 [dendrite development] GO:0016594 [glycine binding] GO:0017146 [NMDA selective glutamate receptor complex] GO:0030054 [cell junction] GO:0030425 [dendrite] GO:0034220 [ion transmembrane transport] GO:0035235 [ionotropic glutamate receptor signaling pathway] GO:0035249 [synaptic transmission, glutamatergic] GO:0042802 [identical protein binding] GO:0043005 [neuron projection] GO:0043025 [neuronal cell body] GO:0045202 [synapse] GO:0045211 [postsynaptic membrane] GO:0045471 [response to ethanol] GO:0051721 [protein phosphatase 2A binding] GO:0060134 [prepulse inhibition] GO:0070588 [calcium ion transmembrane transport] Show all	1115 aa 125.5 kDa	Yes	3