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Weak to moderate nuclear staining was observed in a few cases of melanoma, testis and squamous cell carcinomas. Other cancer tissues were negative.
GENE INFORMATION
Gene name
MAGEB3 (HGNC Symbol)
Synonyms
CT3.5
Description
Melanoma antigen family B3 (HGNC Symbol)
Entrez gene summary
This gene is a MAGE-B subfamily member of the MAGE gene family. MAGE family member proteins direct the expression of tumor antigens recognized on a human melanoma by autologous cytolytic T lymphocytes. There are two known clusters of MAGE genes on chromosome X. The members of the MAGE-A subfamily are located in the Xq28 region, while the members of the MAGE-B subfamily are clustered in the Xp21 region. [provided by RefSeq, Jul 2008]
