Cell atlas - RYR3 - The Human Protein Atlas

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RYR3

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Vesicles

Human cell
	Vesicles

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GENERAL INFORMATION
Gene name	RYR3
Gene description	Ryanodine receptor 3
Protein class	Plasma proteins Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to vesicles.
RNA cell category	Cell line enhanced (RH-30)
Protein evidence	Evidence at protein level
Main location	Localized to the Vesicles (uncertain)

DATA RELIABILITY
Reliability score	Uncertain based on 1 antibody. HPA062004
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (RH-30) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to vesicles.

Main location

Vesicles (uncertain)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA062004	RH-30	Vesicles
	HPA062004	U-2 OS	Vesicles

GENE INFORMATION
Gene name	RYR3
Synonyms
Description	Ryanodine receptor 3 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a ryanodine receptor, which functions to release calcium from intracellular storage for use in many cellular processes. For example, the encoded protein is involved in skeletal muscle contraction by releasing calcium from the sarcoplasmic reticulum followed by depolarization of T-tubules. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Chromosome	15
Cytoband
Chromosome location (bp)	33310945 - 33866121
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000198838 (version 83.38)
Entrez gene	6263
UniProt	Q15413 (UniProt - Evidence at protein level)
neXtProt	NX_Q15413
Antibodypedia	RYR3 antibodies

PROTEIN BROWSER

RYR3-001	RYR3-002	RYR3-008	RYR3-009	RYR3-010	RYR3-011	RYR3-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RYR3-001 ENSP00000489262 ENST00000634891		Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005216 [ion channel activity] GO:0005219 [ryanodine-sensitive calcium-release channel activity] GO:0005262 [calcium channel activity] GO:0005488 [binding] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005829 [cytosol] GO:0006811 [ion transport] GO:0006874 [cellular calcium ion homeostasis] GO:0006941 [striated muscle contraction] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030314 [junctional membrane complex] GO:0033017 [sarcoplasmic reticulum membrane] GO:0048471 [perinuclear region of cytoplasm] GO:0048763 [calcium-induced calcium release activity] GO:0051481 [negative regulation of cytosolic calcium ion concentration] GO:0055085 [transmembrane transport] GO:0070588 [calcium ion transmembrane transport] Show all	4870 aa 552 kDa	No	6
RYR3-002 ENSP00000399610 ENST00000415757	Q15413 [Direct mapping] Ryanodine receptor 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Show all	GO:0005216 [ion channel activity] GO:0005219 [ryanodine-sensitive calcium-release channel activity] GO:0005262 [calcium channel activity] GO:0005488 [binding] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0006811 [ion transport] GO:0006816 [calcium ion transport] GO:0006874 [cellular calcium ion homeostasis] GO:0015278 [calcium-release channel activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0033017 [sarcoplasmic reticulum membrane] GO:0034220 [ion transmembrane transport] GO:0051289 [protein homotetramerization] GO:0055085 [transmembrane transport] GO:0070588 [calcium ion transmembrane transport] GO:0071277 [cellular response to calcium ion] GO:0071286 [cellular response to magnesium ion] GO:0071313 [cellular response to caffeine] GO:0071318 [cellular response to ATP] Show all	4865 aa 551.5 kDa	No	6
RYR3-008 ENSP00000373884 ENST00000389232	Q15413 [Direct mapping] Ryanodine receptor 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Plasma proteins Show all	GO:0005216 [ion channel activity] GO:0005219 [ryanodine-sensitive calcium-release channel activity] GO:0005262 [calcium channel activity] GO:0005488 [binding] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0006811 [ion transport] GO:0006816 [calcium ion transport] GO:0006874 [cellular calcium ion homeostasis] GO:0015278 [calcium-release channel activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0033017 [sarcoplasmic reticulum membrane] GO:0034220 [ion transmembrane transport] GO:0051289 [protein homotetramerization] GO:0055085 [transmembrane transport] GO:0070588 [calcium ion transmembrane transport] GO:0071277 [cellular response to calcium ion] GO:0071286 [cellular response to magnesium ion] GO:0071313 [cellular response to caffeine] GO:0071318 [cellular response to ATP] Show all	4869 aa 552 kDa	No	6
RYR3-009 ENSP00000489294 ENST00000634750		Predicted intracellular proteins Show all		46 aa 5 kDa	No	0
RYR3-010 ENSP00000489529 ENST00000634418		Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Show all	GO:0005216 [ion channel activity] GO:0005219 [ryanodine-sensitive calcium-release channel activity] GO:0005262 [calcium channel activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0006811 [ion transport] GO:0006874 [cellular calcium ion homeostasis] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] GO:0070588 [calcium ion transmembrane transport] Show all	4859 aa 550.8 kDa	No	6
RYR3-011 ENSP00000489346 ENST00000634730		Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Show all	GO:0005216 [ion channel activity] GO:0005219 [ryanodine-sensitive calcium-release channel activity] GO:0006811 [ion transport] GO:0006874 [cellular calcium ion homeostasis] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] Show all	615 aa 70.7 kDa	No	4
RYR3-201 ENSP00000483166 ENST00000622037	A0A087X080 [Direct mapping] Ryanodine receptor 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Show all	GO:0005216 [ion channel activity] GO:0005219 [ryanodine-sensitive calcium-release channel activity] GO:0005262 [calcium channel activity] GO:0005488 [binding] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005623 [cell] GO:0006811 [ion transport] GO:0006874 [cellular calcium ion homeostasis] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] GO:0070588 [calcium ion transmembrane transport] Show all	4873 aa 552.5 kDa	No	6

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.