Expression of GRK5 in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

G protein-coupled receptor kinase 5

Protein class

Enzymes, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

CAB025579

GENE INFORMATION
Gene name	GRK5 (HGNC Symbol)
Synonyms	GPRK5
Description	G protein-coupled receptor kinase 5 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. It has also been shown to play a role in regulating the motility of polymorphonuclear leukocytes (PMNs). [provided by RefSeq, Jul 2008]
Chromosome	10
Cytoband	q26.11
Chromosome location (bp)	119207589 - 119459742
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000198873 (version 83.38)
Entrez gene	2869
UniProt	P34947 (UniProt - Evidence at protein level)
neXtProt	NX_P34947
Antibodypedia	GRK5 antibodies

PROTEIN BROWSER

GRK5-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GRK5-002 ENSP00000376609 ENST00000392870	P34947 [Direct mapping] G protein-coupled receptor kinase 5 Show all	Enzymes ENZYME proteins Transferases Kinases AGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002029 [desensitization of G-protein coupled receptor protein signaling pathway] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004703 [G-protein coupled receptor kinase activity] GO:0005080 [protein kinase C binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005543 [phospholipid binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0006468 [protein phosphorylation] GO:0006915 [apoptotic process] GO:0007188 [adenylate cyclase-modulating G-protein coupled receptor signaling pathway] GO:0007217 [tachykinin receptor signaling pathway] GO:0008277 [regulation of G-protein coupled receptor protein signaling pathway] GO:0008284 [positive regulation of cell proliferation] GO:0016055 [Wnt signaling pathway] GO:0031965 [nuclear membrane] GO:0042493 [response to drug] GO:0043066 [negative regulation of apoptotic process] GO:0045444 [fat cell differentiation] GO:0046777 [protein autophosphorylation] GO:0047696 [beta-adrenergic receptor kinase activity] GO:0051726 [regulation of cell cycle] Show all	590 aa 67.8 kDa	No	0