Expression of CAPZA2 in cancer - Summary

CANCER ATLAS

Gene description

Capping protein (actin filament) muscle Z-line, alpha 2

Protein class

Plasma proteins, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA007470

GENE INFORMATION
Gene name	CAPZA2 (HGNC Symbol)
Synonyms	CAPPA2, CAPZ
Description	Capping protein (actin filament) muscle Z-line, alpha 2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the F-actin capping protein alpha subunit family. It is the alpha subunit of the barbed-end actin binding protein Cap Z. By capping the barbed end of actin filaments, Cap Z regulates the growth of the actin filaments at the barbed end. [provided by RefSeq, Jul 2008]
Chromosome	7
Cytoband	q31.2
Chromosome location (bp)	116811070 - 116922049
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000198898 (version 83.38)
Entrez gene	830
UniProt	P47755 (UniProt - Evidence at protein level)
neXtProt	NX_P47755
Antibodypedia	CAPZA2 antibodies

PROTEIN BROWSER

CAPZA2-002	CAPZA2-006	CAPZA2-009	CAPZA2-010	CAPZA2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CAPZA2-002 ENSP00000354947 ENST00000361183	P47755 [Direct mapping] F-actin-capping protein subunit alpha-2 A4D0V4 [Target identity:100%; Query identity:100%] Capping protein (Actin filament) muscle Z-line, alpha 2; Capping protein (Actin filament) muscle Z-line, alpha 2, isoform CRA_b; cDNA, FLJ95684, Homo sapiens capping protein (actin filament) muscle Z-line, alpha2 (CAPZA2), mRNA Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005829 [cytosol] GO:0005903 [brush border] GO:0006461 [protein complex assembly] GO:0006928 [movement of cell or subcellular component] GO:0007596 [blood coagulation] GO:0008290 [F-actin capping protein complex] GO:0015629 [actin cytoskeleton] GO:0016020 [membrane] GO:0030863 [cortical cytoskeleton] GO:0045087 [innate immune response] GO:0051016 [barbed-end actin filament capping] GO:0070062 [extracellular exosome] Show all	286 aa 32.9 kDa	No	0
CAPZA2-006 ENSP00000419484 ENST00000490693	C9JUG7 [Direct mapping] F-actin-capping protein subunit alpha-2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008290 [F-actin capping protein complex] GO:0051016 [barbed-end actin filament capping] Show all	146 aa 16.7 kDa	No	0
CAPZA2-009 ENSP00000420640 ENST00000464223	C9JCZ4 [Direct mapping] F-actin-capping protein subunit alpha-2 Show all	MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	34 aa 4 kDa	No	0
CAPZA2-010 ENSP00000418262 ENST00000484325	C9J7V0 [Direct mapping] F-actin-capping protein subunit alpha-2 Show all	MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	34 aa 4 kDa	No	0
CAPZA2-201 ENSP00000485993 ENST00000628758	A0A0D9SET8 [Direct mapping] F-actin-capping protein subunit alpha-2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008290 [F-actin capping protein complex] GO:0051016 [barbed-end actin filament capping] Show all	174 aa 20.1 kDa	No	0