Cell atlas - MAP3K3 - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

MAP3K3

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS MOUSE CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm

Human cell
	Nucleoplasm

Please wait until image is loaded before changing channels

GENERAL INFORMATION
Gene name	MAP3K3
Gene description	Mitogen-activated protein kinase kinase kinase 3
Protein class	Cancer-related genes Enzymes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoplasm.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA035410
	SHOW MORE

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoplasm.

Main location

Nucleoplasm (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA035410	HEK 293	No staining
	HPA035410	U-2 OS	Nucleoplasm
	HPA035410	U-251 MG	Nucleoplasm

MOUSE CELLS

Main location

Not available

Mouse gene

ENSMUSG00000020700 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA035410	NIH 3T3	No staining

GENE INFORMATION
Gene name	MAP3K3 (HGNC Symbol)
Synonyms	MAPKKK3, MEKK3
Description	Mitogen-activated protein kinase kinase kinase 3 (HGNC Symbol)
Entrez gene summary	This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	q23.3
Chromosome location (bp)	63622415 - 63696303
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000198909 (version 83.38)
Entrez gene	4215
UniProt	Q99759 (UniProt - Evidence at protein level)
neXtProt	NX_Q99759
Antibodypedia	MAP3K3 antibodies

PROTEIN BROWSER

MAP3K3-001	MAP3K3-002	MAP3K3-004	MAP3K3-005	MAP3K3-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MAP3K3-001 ENSP00000354927 ENST00000361357	Q99759 [Direct mapping] Mitogen-activated protein kinase kinase kinase 3 Show all	Enzymes ENZYME proteins Transferases Kinases STE Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000165 [MAPK cascade] GO:0000186 [activation of MAPKK activity] GO:0000187 [activation of MAPK activity] GO:0001568 [blood vessel development] GO:0004672 [protein kinase activity] GO:0004708 [MAP kinase kinase activity] GO:0004709 [MAP kinase kinase kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005622 [intracellular] GO:0005829 [cytosol] GO:0006468 [protein phosphorylation] GO:0035556 [intracellular signal transduction] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0046777 [protein autophosphorylation] GO:0046872 [metal ion binding] GO:1900745 [positive regulation of p38MAPK cascade] Show all	657 aa 74.1 kDa	No	0
MAP3K3-002 ENSP00000464130 ENST00000584573	J3QRB6 [Direct mapping] Mitogen-activated protein kinase kinase kinase 3 Show all	MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000165 [MAPK cascade] GO:0000187 [activation of MAPK activity] GO:0004672 [protein kinase activity] GO:0004708 [MAP kinase kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005622 [intracellular] GO:0006468 [protein phosphorylation] Show all	653 aa 73.7 kDa	No	0
MAP3K3-004 ENSP00000354485 ENST00000361733	Q99759 [Direct mapping] Mitogen-activated protein kinase kinase kinase 3 Show all	Enzymes ENZYME proteins Transferases Kinases STE Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000165 [MAPK cascade] GO:0000186 [activation of MAPKK activity] GO:0000187 [activation of MAPK activity] GO:0004672 [protein kinase activity] GO:0004708 [MAP kinase kinase activity] GO:0004709 [MAP kinase kinase kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005622 [intracellular] GO:0005829 [cytosol] GO:0006468 [protein phosphorylation] GO:0035556 [intracellular signal transduction] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0046777 [protein autophosphorylation] GO:0046872 [metal ion binding] Show all	626 aa 70.9 kDa	No	0
MAP3K3-005 ENSP00000462086 ENST00000577395	J3KRN4 [Direct mapping] Mitogen-activated protein kinase kinase kinase 3 Show all	MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000165 [MAPK cascade] GO:0000187 [activation of MAPK activity] GO:0004672 [protein kinase activity] GO:0004708 [MAP kinase kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005622 [intracellular] GO:0006468 [protein phosphorylation] Show all	622 aa 70.5 kDa	No	0
MAP3K3-007 ENSP00000461988 ENST00000579585	Q99759 [Direct mapping] Mitogen-activated protein kinase kinase kinase 3 Show all	Enzymes ENZYME proteins Transferases Kinases STE Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000165 [MAPK cascade] GO:0000186 [activation of MAPKK activity] GO:0000187 [activation of MAPK activity] GO:0004672 [protein kinase activity] GO:0004708 [MAP kinase kinase activity] GO:0004709 [MAP kinase kinase kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005622 [intracellular] GO:0005829 [cytosol] GO:0006468 [protein phosphorylation] GO:0035556 [intracellular signal transduction] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0046777 [protein autophosphorylation] GO:0046872 [metal ion binding] Show all	657 aa 74.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.