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Cancer tissues showed weak to moderate nuclear immunoreactivity. A few cases of testicular and endometrial cancers expressed strong nuclear staining. Carcinoids and several cases of melanomas, prostate, renal and liver cancers were negative.
GENE INFORMATION
Gene name
SREBF2 (HGNC Symbol)
Synonyms
bHLHd2, SREBP2
Description
Sterol regulatory element binding transcription factor 2 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the a ubiquitously expressed transcription factor that controls cholesterol homeostasis by regulating transcription of sterol-regulated genes. The encoded protein contains a basic helix-loop-helix-leucine zipper (bHLH-Zip) domain and binds the sterol regulatory element 1 motif. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]