Expression of APRT in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Adenine phosphoribosyltransferase

Protein class

Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA026681

GENE INFORMATION
Gene name	APRT
Synonyms
Description	Adenine phosphoribosyltransferase (HGNC Symbol)
Entrez gene summary	Adenine phosphoribosyltransferase belongs to the purine/pyrimidine phosphoribosyltransferase family. A conserved feature of this gene is the distribution of CpG dinucleotides. This enzyme catalyzes the formation of AMP and inorganic pyrophosphate from adenine and 5-phosphoribosyl-1-pyrophosphate (PRPP). It also produces adenine as a by-product of the polyamine biosynthesis pathway. A homozygous deficiency in this enzyme causes 2,8-dihydroxyadenine urolithiasis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	16
Cytoband	q24.3
Chromosome location (bp)	88809339 - 88811944
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000198931 (version 83.38)
Entrez gene	353
UniProt	P07741 (UniProt - Evidence at protein level)
neXtProt	NX_P07741
Antibodypedia	APRT antibodies

PROTEIN BROWSER

APRT-001	APRT-002	APRT-007	APRT-008	APRT-011

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
APRT-001 ENSP00000367615 ENST00000378364	P07741 [Direct mapping] Adenine phosphoribosyltransferase Show all	Enzymes ENZYME proteins Transferases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002055 [adenine binding] GO:0003999 [adenine phosphoribosyltransferase activity] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006144 [purine nucleobase metabolic process] GO:0006166 [purine ribonucleoside salvage] GO:0006168 [adenine salvage] GO:0007595 [lactation] GO:0007625 [grooming behavior] GO:0009116 [nucleoside metabolic process] GO:0016208 [AMP binding] GO:0032869 [cellular response to insulin stimulus] GO:0043101 [purine-containing compound salvage] GO:0044209 [AMP salvage] GO:0044281 [small molecule metabolic process] GO:0055086 [nucleobase-containing small molecule metabolic process] GO:0070062 [extracellular exosome] Show all	180 aa 19.6 kDa	No	0
APRT-002 ENSP00000397007 ENST00000426324	P07741 [Direct mapping] Adenine phosphoribosyltransferase Show all	Enzymes ENZYME proteins Transferases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003999 [adenine phosphoribosyltransferase activity] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006144 [purine nucleobase metabolic process] GO:0009116 [nucleoside metabolic process] GO:0016208 [AMP binding] GO:0043101 [purine-containing compound salvage] GO:0044209 [AMP salvage] GO:0044281 [small molecule metabolic process] GO:0055086 [nucleobase-containing small molecule metabolic process] GO:0070062 [extracellular exosome] Show all	134 aa 14.6 kDa	No	0
APRT-007 ENSP00000455749 ENST00000567713	H3BQF1 [Direct mapping] Adenine phosphoribosyltransferase Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0009116 [nucleoside metabolic process] GO:0016740 [transferase activity] Show all	149 aa 16.4 kDa	No	0
APRT-008 ENSP00000455692 ENST00000569616	H3BQB1 [Direct mapping] Adenine phosphoribosyltransferase Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0009116 [nucleoside metabolic process] GO:0016740 [transferase activity] Show all	162 aa 17.5 kDa	No	0
APRT-011 ENSP00000456012 ENST00000563655	H3BQZ9 [Direct mapping] Adenine phosphoribosyltransferase Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0009116 [nucleoside metabolic process] GO:0016740 [transferase activity] Show all	153 aa 16.6 kDa	No	0