Cell atlas - MAGEE1 - The Human Protein Atlas

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MAGEE1

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS CELL CYCLE

GENE/PROTEIN

Antibody validation

Dictionary
	Cytokinetic bridge
	Cytosol

Human cell
	Cytosol
	Microtubules

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GENERAL INFORMATION
Gene name	MAGEE1
Gene description	Melanoma antigen family E1
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the cytosol. In addition localized to the cytokinetic bridge.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (approved)
Additional location	In addition localized to the Cytokinetic bridge (approved)
Single-cell variation	Single-cell variation in protein expression observed.
Cell cycle dependency	Cell cycle dependent expression determined by biological definition

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA003047
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the cytosol. In addition localized to the cytokinetic bridge.

Main location

Cytosol (approved)

Additional location

Cytokinetic bridge (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA003047	A549	Cytokinetic bridge	Intensity	Intensity
	HPA003047	A549	Cytosol
	HPA003047	PC-3	Cytosol
	HPA003047	U-2 OS	Cytosol

CELL CYCLE
Summary	Expression has cell cycle dependency according to biological definition
Intensity variation	Cytokinetic bridge

GENE INFORMATION
Gene name	MAGEE1 (HGNC Symbol)
Synonyms	DAMAGE, KIAA1587
Description	Melanoma antigen family E1 (HGNC Symbol)
Entrez gene summary	This gene encodes an alpha-dystrobrevin-associated MAGE (melanoma-associated antigen) protein, which is a member of the MAGE family. The protein contains a nuclear localization signal in the N-terminus, 30 12-amino acid repeats beginning at nt 60 with the consensus sequence ASEGPSTSVLPT, and two MAGE domains in the C-terminus. It may play a signaling role in brain, muscle, and peripheral nerve. This gene is located on X chromosome in a region containing loci linked to mental retardation. [provided by RefSeq, Mar 2010]
Chromosome	X
Cytoband	q13.3
Chromosome location (bp)	76427724 - 76431353
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000198934 (version 83.38)
Entrez gene	57692
UniProt	Q9HCI5 (UniProt - Evidence at protein level)
neXtProt	NX_Q9HCI5
Antibodypedia	MAGEE1 antibodies

PROTEIN BROWSER

MAGEE1-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MAGEE1-001 ENSP00000354912 ENST00000361470	Q9HCI5 [Direct mapping] Melanoma-associated antigen E1 Show all	MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005886 [plasma membrane] GO:0008150 [biological_process] GO:0016010 [dystrophin-associated glycoprotein complex] GO:0030425 [dendrite] GO:0045211 [postsynaptic membrane] GO:0048471 [perinuclear region of cytoplasm] Show all	957 aa 103.3 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.